Relationship among human papillomavirus infection, p16INK4a, p53 and NF-κB activation in penile cancer from northern Thailand

• Main Authors: Senba M., Mori N., Fujita S., Jutavijittum P., Yousukh A., Toriyama K., Wada A.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954893556&partnerID=40&md5=ca594d6ead083a7a82456a3911a077d3; http://cmuir.cmu.ac.th/handle/6653943832/3653
• Institution: Chiang Mai University

Human papillomavirus (HPV) E6 and E7 onco-proteins are essential factors for HPV oncogenesis. These E6 and E7 gene products play a central role in the induction of malignant transformation by interacting with several cellular regulatory proteins such as p16INK4a, p53 and nuclear factor κB (NF-κB). I...