Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi

Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5...

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Main Authors:	Reutrakul V., Anantachoke N., Pohmakotr M., Jaipetch T., Yoosook C., Kasisit J., Napaswa C., Panthong A., Santisuk T., Prabpai S., Kongsaeree P., Tuchinda P.
Format:	Article
Language:	English
Published:	2014
Online Access:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77749316840&partnerID=40&md5=3e02afdc1c6e5cb5b957ff9f3c5f54a0 http://cmuir.cmu.ac.th/handle/6653943832/3675
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Institution:	Chiang Mai University
Language:	English

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spelling	th-cmuir.6653943832-36752014-08-30T02:35:11Z Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi Reutrakul V. Anantachoke N. Pohmakotr M. Jaipetch T. Yoosook C. Kasisit J. Napaswa C. Panthong A. Santisuk T. Prabpai S. Kongsaeree P. Tuchinda P. Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York. 2014-08-30T02:35:11Z 2014-08-30T02:35:11Z 2010 Article 320943 10.1055/s-0029-1186193 19830655 PLMEA http://www.scopus.com/inward/record.url?eid=2-s2.0-77749316840&partnerID=40&md5=3e02afdc1c6e5cb5b957ff9f3c5f54a0 http://cmuir.cmu.ac.th/handle/6653943832/3675 English
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
language	English
description	Two new lupanes, 2-acetoxy-3-hydroxy-19-hydrogen-lup-20(29)-en-28-oic acid (2-acetoxyalphitolic acid) (1) and 2-hydroxy-3-acetoxy-19-hydrogen-lup-20(29)- en-28-oic acid (3-acetoxyalphitolic acid) (2), together with the known betulinic acid (3), betulin (4), and stimasterol-3-O - D-glucopyranoside (5), were isolated from the leaves and twigs of Garcinia hanburyi. Compounds 13 were also isolated from the resin of this plant. The structure of 2 was confirmed by single-crystal X-ray diffraction analysis. All of the lupanes (14) displayed anti-HIV1 activities in the anti-HIV1 reverse transcriptase (ICvalues 16.3116.9g/mL) and syncytium assays (EC5.673.6g/mL, SI 1.73.3). Moreover compounds 14 exhibited anti-inflammatory activity in an ethyl phenylpropiolate (EPP)-induced ear edema model. © Georg Thieme Verlag KG Stuttgart New York.
format	Article
author	Reutrakul V. Anantachoke N. Pohmakotr M. Jaipetch T. Yoosook C. Kasisit J. Napaswa C. Panthong A. Santisuk T. Prabpai S. Kongsaeree P. Tuchinda P.
spellingShingle	Reutrakul V. Anantachoke N. Pohmakotr M. Jaipetch T. Yoosook C. Kasisit J. Napaswa C. Panthong A. Santisuk T. Prabpai S. Kongsaeree P. Tuchinda P. Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
author_facet	Reutrakul V. Anantachoke N. Pohmakotr M. Jaipetch T. Yoosook C. Kasisit J. Napaswa C. Panthong A. Santisuk T. Prabpai S. Kongsaeree P. Tuchinda P.
author_sort	Reutrakul V.
title	Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_short	Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_full	Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_fullStr	Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_full_unstemmed	Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
title_sort	anti-hiv1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi
publishDate	2014
url	http://www.scopus.com/inward/record.url?eid=2-s2.0-77749316840&partnerID=40&md5=3e02afdc1c6e5cb5b957ff9f3c5f54a0 http://cmuir.cmu.ac.th/handle/6653943832/3675
_version_	1681420093233299456

Anti-HIV1 and anti-inflammatory lupanes from the leaves, twigs, and resin of garcinia hanburyi

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