Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children

To evaluate the immunogenicity and safety of the monovalent pandemic influenza A (H1N1) 2009 (pH1N1) vaccine in HIV-infected Thai children, 2 doses, 28days apart, of non-adjuvant monovalent pH1N1 vaccine (Panenza® by Sanofi Pasteur, 15μg/dose) provided by the National Health Promotion Program of the...

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Main Authors: Phongsamart W., Sirisanthana V., Wittawatmongkol O., Maleesatharn A., Sudjaritruk T., Chearskul P., Aurpibul L., Sirisanthana T., Chokephaibulkit K.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-82455192719&partnerID=40&md5=78078c78735aee2d0fe08d311fee9c6c
http://cmuir.cmu.ac.th/handle/6653943832/3710
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-37102014-08-30T02:35:14Z Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children Phongsamart W. Sirisanthana V. Wittawatmongkol O. Maleesatharn A. Sudjaritruk T. Chearskul P. Aurpibul L. Sirisanthana T. Chokephaibulkit K. To evaluate the immunogenicity and safety of the monovalent pandemic influenza A (H1N1) 2009 (pH1N1) vaccine in HIV-infected Thai children, 2 doses, 28days apart, of non-adjuvant monovalent pH1N1 vaccine (Panenza® by Sanofi Pasteur, 15μg/dose) provided by the National Health Promotion Program of the Thai Ministry of Public Health were given to HIV-infected children. Immunogenicity was measured by hemagglutination inhibition test (HAI) using two antigens, pH1N1 (A/Thailand/104/09) and seasonal influenza A H1N1 (A/Brisbane/59/07-like), at baseline, and 28days after each dose. Serologic response was defined as four-fold rising of HAI titer or HAI titer ≥1:40 for those with baseline titer ≤1:10. Adverse events were recorded for 7days after each vaccination. Of the 119 HIV-infected children enrolled, 60 (50.4%) were female with a median (IQR) age of 10.4 (7.2-13.7)years. All but 2 (98.3%) children were receiving antiretroviral therapy. At baseline, the median CD4 cell count was 782 (570-1149)cells/mm3, 91 (80.5%) children had HIV RNA level <40copies/ml. The baseline HAI titer ≥1:40 for pH1N1 and seasonal H1N1 were 45.4%, and 39.5%, respectively. At 28days after doses 1 and 2, the serologic response rates for pH1N1 were 54.2% and 67.8% with the geometric mean titer of 109.9 and 141.8; and serologic response rate when tested with seasonal H1N1 were 2.5% and 3.5%, respectively. The presence of baseline HAI titer for pH1N1 or seasonal H1N1 was found to be associated with serologic response. The vaccine was well tolerated. The results suggested that monovalent pH1N1 vaccine was immunogenic and safe in well controlled HIV-infected children with low level of cross reacting antibody to seasonal H1N1. © 2011 Elsevier Ltd. 2014-08-30T02:35:14Z 2014-08-30T02:35:14Z 2011 Article 0264410X 10.1016/j.vaccine.2011.08.101 VACCD http://www.scopus.com/inward/record.url?eid=2-s2.0-82455192719&partnerID=40&md5=78078c78735aee2d0fe08d311fee9c6c http://cmuir.cmu.ac.th/handle/6653943832/3710 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description To evaluate the immunogenicity and safety of the monovalent pandemic influenza A (H1N1) 2009 (pH1N1) vaccine in HIV-infected Thai children, 2 doses, 28days apart, of non-adjuvant monovalent pH1N1 vaccine (Panenza® by Sanofi Pasteur, 15μg/dose) provided by the National Health Promotion Program of the Thai Ministry of Public Health were given to HIV-infected children. Immunogenicity was measured by hemagglutination inhibition test (HAI) using two antigens, pH1N1 (A/Thailand/104/09) and seasonal influenza A H1N1 (A/Brisbane/59/07-like), at baseline, and 28days after each dose. Serologic response was defined as four-fold rising of HAI titer or HAI titer ≥1:40 for those with baseline titer ≤1:10. Adverse events were recorded for 7days after each vaccination. Of the 119 HIV-infected children enrolled, 60 (50.4%) were female with a median (IQR) age of 10.4 (7.2-13.7)years. All but 2 (98.3%) children were receiving antiretroviral therapy. At baseline, the median CD4 cell count was 782 (570-1149)cells/mm3, 91 (80.5%) children had HIV RNA level <40copies/ml. The baseline HAI titer ≥1:40 for pH1N1 and seasonal H1N1 were 45.4%, and 39.5%, respectively. At 28days after doses 1 and 2, the serologic response rates for pH1N1 were 54.2% and 67.8% with the geometric mean titer of 109.9 and 141.8; and serologic response rate when tested with seasonal H1N1 were 2.5% and 3.5%, respectively. The presence of baseline HAI titer for pH1N1 or seasonal H1N1 was found to be associated with serologic response. The vaccine was well tolerated. The results suggested that monovalent pH1N1 vaccine was immunogenic and safe in well controlled HIV-infected children with low level of cross reacting antibody to seasonal H1N1. © 2011 Elsevier Ltd.
format Article
author Phongsamart W.
Sirisanthana V.
Wittawatmongkol O.
Maleesatharn A.
Sudjaritruk T.
Chearskul P.
Aurpibul L.
Sirisanthana T.
Chokephaibulkit K.
spellingShingle Phongsamart W.
Sirisanthana V.
Wittawatmongkol O.
Maleesatharn A.
Sudjaritruk T.
Chearskul P.
Aurpibul L.
Sirisanthana T.
Chokephaibulkit K.
Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children
author_facet Phongsamart W.
Sirisanthana V.
Wittawatmongkol O.
Maleesatharn A.
Sudjaritruk T.
Chearskul P.
Aurpibul L.
Sirisanthana T.
Chokephaibulkit K.
author_sort Phongsamart W.
title Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children
title_short Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children
title_full Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children
title_fullStr Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children
title_full_unstemmed Immunogenicity and safety of monovalent influenza A (H1N1) 2009 in HIV-infected Thai children
title_sort immunogenicity and safety of monovalent influenza a (h1n1) 2009 in hiv-infected thai children
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-82455192719&partnerID=40&md5=78078c78735aee2d0fe08d311fee9c6c
http://cmuir.cmu.ac.th/handle/6653943832/3710
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