Pure curcumin inhibits exogenous Wilms' tumor (WT1) (+/+) isoform protein via degradation pathway and protein kinase C in transfected U937 cells

• Main Authors: Semsri S., Anuchapreeda S., Intasai N., Jomgeow T., Tima S., Sweeney C., Limtrakul P.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-80655146486&partnerID=40&md5=533ab12c4070293e41f60994352725ed; http://cmuir.cmu.ac.th/handle/6653943832/3717
• Institution: Chiang Mai University

Wilms' tumor (WT1) gene overexpresses in leukemic cells which is alternatively spliced at two sites, yielding four isoforms: WT1 (+/+), (+/-), (-/+), and (-/-). Curcumin is one of major active components of the spice turmeric, widely known as anticancer. This study investigated the effects and...