Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota

Conventional wisdom holds that microbes support their growth in vertebrate hosts by exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) confers a marked growth advantage on Salmonella enterica serovar Typhimurium (S. Typhimurium) in the lumen of the i...

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Main Authors: Thiennimitr P., Winter S.E., Winter M.G., Xavier M.N., Tolstikov V., Huseby D.L., Sterzenbach T., Tsolis R.M., Roth J.R., Baumler A.J.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-80054806900&partnerID=40&md5=988d45bbfea0971e7c6850ae0f2f03e3
http://cmuir.cmu.ac.th/handle/6653943832/3718
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-37182014-08-30T02:35:14Z Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota Thiennimitr P. Winter S.E. Winter M.G. Xavier M.N. Tolstikov V. Huseby D.L. Sterzenbach T. Tsolis R.M. Roth J.R. Baumler A.J. Conventional wisdom holds that microbes support their growth in vertebrate hosts by exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) confers a marked growth advantage on Salmonella enterica serovar Typhimurium (S. Typhimurium) in the lumen of the inflamed intestine. In the anaerobic environment of the gut, ethanolamine supports little or no growth by fermentation. However, S. Typhimurium is able to use this carbon source by inducing the gut to produce a respiratory electron acceptor (tetrathionate), which supports anaerobic growth on ethanolamine. The gut normally converts ambient hydrogen sulfide to thiosulfate, which it then oxidizes further to tetrathionate during inflammation. Evidence is provided that S. Typhimurium's growth advantage in an inflamed gut is because of its ability to respire ethanolamine, which is released from host tissue, but is not utilizable by competing bacteria. By inducing intestinal inflammation, S. Typhimurium sidesteps nutritional competition and gains the ability to use an abundant simple substrate, ethanolamine, which is provided by the host. 2014-08-30T02:35:14Z 2014-08-30T02:35:14Z 2011 Article 278424 10.1073/pnas.1107857108 PNASA http://www.scopus.com/inward/record.url?eid=2-s2.0-80054806900&partnerID=40&md5=988d45bbfea0971e7c6850ae0f2f03e3 http://cmuir.cmu.ac.th/handle/6653943832/3718 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Conventional wisdom holds that microbes support their growth in vertebrate hosts by exploiting a large variety of nutrients. We show here that use of a specific nutrient (ethanolamine) confers a marked growth advantage on Salmonella enterica serovar Typhimurium (S. Typhimurium) in the lumen of the inflamed intestine. In the anaerobic environment of the gut, ethanolamine supports little or no growth by fermentation. However, S. Typhimurium is able to use this carbon source by inducing the gut to produce a respiratory electron acceptor (tetrathionate), which supports anaerobic growth on ethanolamine. The gut normally converts ambient hydrogen sulfide to thiosulfate, which it then oxidizes further to tetrathionate during inflammation. Evidence is provided that S. Typhimurium's growth advantage in an inflamed gut is because of its ability to respire ethanolamine, which is released from host tissue, but is not utilizable by competing bacteria. By inducing intestinal inflammation, S. Typhimurium sidesteps nutritional competition and gains the ability to use an abundant simple substrate, ethanolamine, which is provided by the host.
format Article
author Thiennimitr P.
Winter S.E.
Winter M.G.
Xavier M.N.
Tolstikov V.
Huseby D.L.
Sterzenbach T.
Tsolis R.M.
Roth J.R.
Baumler A.J.
spellingShingle Thiennimitr P.
Winter S.E.
Winter M.G.
Xavier M.N.
Tolstikov V.
Huseby D.L.
Sterzenbach T.
Tsolis R.M.
Roth J.R.
Baumler A.J.
Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
author_facet Thiennimitr P.
Winter S.E.
Winter M.G.
Xavier M.N.
Tolstikov V.
Huseby D.L.
Sterzenbach T.
Tsolis R.M.
Roth J.R.
Baumler A.J.
author_sort Thiennimitr P.
title Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
title_short Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
title_full Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
title_fullStr Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
title_full_unstemmed Intestinal inflammation allows Salmonella to use ethanolamine to compete with the microbiota
title_sort intestinal inflammation allows salmonella to use ethanolamine to compete with the microbiota
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-80054806900&partnerID=40&md5=988d45bbfea0971e7c6850ae0f2f03e3
http://cmuir.cmu.ac.th/handle/6653943832/3718
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