Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.

The antifilaricidal drugs ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB), used alone or in combinations against infective third-stage larvae (L3) of nocturnally subperiodic (NSP) Brugia malayi (Narathiwat strain), were tested in vitro for sensitivity, for 7 days. IVM alone reduced...

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Main Authors: Tippawangkosol P., Choochote W., Na-Bangchang K., Jitpakdi A., Pitasawat B., Riyong D.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-20644446884&partnerID=40&md5=c1969eb15a9593f04b43a8137ae70082
http://cmuir.cmu.ac.th/handle/6653943832/3742
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-37422014-08-30T02:35:16Z Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination. Tippawangkosol P. Choochote W. Na-Bangchang K. Jitpakdi A. Pitasawat B. Riyong D. The antifilaricidal drugs ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB), used alone or in combinations against infective third-stage larvae (L3) of nocturnally subperiodic (NSP) Brugia malayi (Narathiwat strain), were tested in vitro for sensitivity, for 7 days. IVM alone reduced larval motility at concentrations of 10(-7), 10(-6), and 10(-5) M on day 3. DEC alone also had this effect at concentrations of 10(-6). 10(-5), and 10(-4) M on day 2. ALB alone did not have this effect throughout the experiment, at various concentrations. However, it had greater effect when used in combination with either DEC or IVM. The result also indicated that DEC or IVM, when used in combination with ALB at concentrations of 10(-6) M/10(-6) M, and 10(-5) M/10(-5) M was effectively better than each drug used alone at those concentrations. When both drug combinations were compared, ALB/DEC seemed to be more effective than ALB/IVM at a concentration of 10(-6) M/10(-6) M on day 3. Although IVM and DEC can reduce larval motility when used alone or in combination with ALB, they cannot kill these larvae in an in vitro cultivation, even at a high concentration (10(-5) M). 2014-08-30T02:35:16Z 2014-08-30T02:35:16Z 2004 Article 01251562 15906628 http://www.scopus.com/inward/record.url?eid=2-s2.0-20644446884&partnerID=40&md5=c1969eb15a9593f04b43a8137ae70082 http://cmuir.cmu.ac.th/handle/6653943832/3742 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The antifilaricidal drugs ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB), used alone or in combinations against infective third-stage larvae (L3) of nocturnally subperiodic (NSP) Brugia malayi (Narathiwat strain), were tested in vitro for sensitivity, for 7 days. IVM alone reduced larval motility at concentrations of 10(-7), 10(-6), and 10(-5) M on day 3. DEC alone also had this effect at concentrations of 10(-6). 10(-5), and 10(-4) M on day 2. ALB alone did not have this effect throughout the experiment, at various concentrations. However, it had greater effect when used in combination with either DEC or IVM. The result also indicated that DEC or IVM, when used in combination with ALB at concentrations of 10(-6) M/10(-6) M, and 10(-5) M/10(-5) M was effectively better than each drug used alone at those concentrations. When both drug combinations were compared, ALB/DEC seemed to be more effective than ALB/IVM at a concentration of 10(-6) M/10(-6) M on day 3. Although IVM and DEC can reduce larval motility when used alone or in combination with ALB, they cannot kill these larvae in an in vitro cultivation, even at a high concentration (10(-5) M).
format Article
author Tippawangkosol P.
Choochote W.
Na-Bangchang K.
Jitpakdi A.
Pitasawat B.
Riyong D.
spellingShingle Tippawangkosol P.
Choochote W.
Na-Bangchang K.
Jitpakdi A.
Pitasawat B.
Riyong D.
Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
author_facet Tippawangkosol P.
Choochote W.
Na-Bangchang K.
Jitpakdi A.
Pitasawat B.
Riyong D.
author_sort Tippawangkosol P.
title Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
title_short Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
title_full Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
title_fullStr Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
title_full_unstemmed Comparative assessment of the in vitro sensitivity of Brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
title_sort comparative assessment of the in vitro sensitivity of brugia malayi infective larvae to albendazole, diethylcarbamazine and ivermectin alone and in combination.
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-20644446884&partnerID=40&md5=c1969eb15a9593f04b43a8137ae70082
http://cmuir.cmu.ac.th/handle/6653943832/3742
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