Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity

• Main Authors: Harcourt B.H., Jukneliene D., Kanjanahaluethai A., Bechill J., Severson K.M., Smith C.M., Rota P.A., Baker S.C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-10044268025&partnerID=40&md5=7c5b29b2581178033f18b4b4f2886707; http://cmuir.cmu.ac.th/handle/6653943832/3744
• Institution: Chiang Mai University

Gene 1 of the coronavirus associated with severe acute respiratory syndrome (SARS) encodes replicase poly-proteins that are predicted to be processed into 16 nonstructural proteins (nsps 1 to 16) by two viral proteases, a papain-like protease (PLpro) and a 3C-like protease (3CLpro). Here, we identif...