The association of hormonal contraceptive use and HPV prevalence

Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to...

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Main Authors: Marks M., Gravitt P.E., Gupta S.B., Liaw K.-L., Kim E., Tadesse A., Phongnarisorn C., Wootipoom V., Yuenyao P., Vipupinyo C., Rugpao S., Sriplienchan S., Celentano D.D.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-79955392446&partnerID=40&md5=d6fcb8d48afb377bd3fc2d1f7fa18108
http://cmuir.cmu.ac.th/handle/6653943832/3748
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spelling th-cmuir.6653943832-37482014-08-30T02:35:16Z The association of hormonal contraceptive use and HPV prevalence Marks M. Gravitt P.E. Gupta S.B. Liaw K.-L. Kim E. Tadesse A. Phongnarisorn C. Wootipoom V. Yuenyao P. Vipupinyo C. Rugpao S. Sriplienchan S. Celentano D.D. Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the association of contraceptive use on the risk for prevalent HPV infection in a cohort of long-term hormonal contraceptive (HC) users. One thousand and seventy (n = 1,070) HIV-negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. Baseline HPV genotype information, recency and duration of HC use, sexual behavior, other sexually transmitted infection (STI) information and cervical cytology and histology were assessed. At enrollment, 19.8% and 11.5% of women were infected with any HPV or any high-risk (HR)-HPV, respectively. After adjustment for age, current and past sexual risk behaviors, STI history and cytology, the use of COCs for >6 years was found to be associated with an increased risk of infection with any HPV [prevalence ratio (PR): 1.88 (1.21, 2.90)] and any HR-HPV [PR: 2.68 (1.47, 4.88)] as compared to never users. Recent, long-term COC use was associated with an increased risk for prevalent HPV infection independent of sexual behavior and cervical abnormalities. No similar association was observed for recent or long duration use of progestin-only contraceptives (i.e., depomedroxyprogesterone acetate). These data suggest that COC use may impact early upstream events in the natural history of HPV infection. © 2010 UICC. 2014-08-30T02:35:16Z 2014-08-30T02:35:16Z 2011 Article 207136 10.1002/ijc.25628 20734390 IJCNA http://www.scopus.com/inward/record.url?eid=2-s2.0-79955392446&partnerID=40&md5=d6fcb8d48afb377bd3fc2d1f7fa18108 http://cmuir.cmu.ac.th/handle/6653943832/3748 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the association of contraceptive use on the risk for prevalent HPV infection in a cohort of long-term hormonal contraceptive (HC) users. One thousand and seventy (n = 1,070) HIV-negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. Baseline HPV genotype information, recency and duration of HC use, sexual behavior, other sexually transmitted infection (STI) information and cervical cytology and histology were assessed. At enrollment, 19.8% and 11.5% of women were infected with any HPV or any high-risk (HR)-HPV, respectively. After adjustment for age, current and past sexual risk behaviors, STI history and cytology, the use of COCs for >6 years was found to be associated with an increased risk of infection with any HPV [prevalence ratio (PR): 1.88 (1.21, 2.90)] and any HR-HPV [PR: 2.68 (1.47, 4.88)] as compared to never users. Recent, long-term COC use was associated with an increased risk for prevalent HPV infection independent of sexual behavior and cervical abnormalities. No similar association was observed for recent or long duration use of progestin-only contraceptives (i.e., depomedroxyprogesterone acetate). These data suggest that COC use may impact early upstream events in the natural history of HPV infection. © 2010 UICC.
format Article
author Marks M.
Gravitt P.E.
Gupta S.B.
Liaw K.-L.
Kim E.
Tadesse A.
Phongnarisorn C.
Wootipoom V.
Yuenyao P.
Vipupinyo C.
Rugpao S.
Sriplienchan S.
Celentano D.D.
spellingShingle Marks M.
Gravitt P.E.
Gupta S.B.
Liaw K.-L.
Kim E.
Tadesse A.
Phongnarisorn C.
Wootipoom V.
Yuenyao P.
Vipupinyo C.
Rugpao S.
Sriplienchan S.
Celentano D.D.
The association of hormonal contraceptive use and HPV prevalence
author_facet Marks M.
Gravitt P.E.
Gupta S.B.
Liaw K.-L.
Kim E.
Tadesse A.
Phongnarisorn C.
Wootipoom V.
Yuenyao P.
Vipupinyo C.
Rugpao S.
Sriplienchan S.
Celentano D.D.
author_sort Marks M.
title The association of hormonal contraceptive use and HPV prevalence
title_short The association of hormonal contraceptive use and HPV prevalence
title_full The association of hormonal contraceptive use and HPV prevalence
title_fullStr The association of hormonal contraceptive use and HPV prevalence
title_full_unstemmed The association of hormonal contraceptive use and HPV prevalence
title_sort association of hormonal contraceptive use and hpv prevalence
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-79955392446&partnerID=40&md5=d6fcb8d48afb377bd3fc2d1f7fa18108
http://cmuir.cmu.ac.th/handle/6653943832/3748
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