Maturation of flaviviruses starts from one or more icosahedrally independent nucleation centres

• Main Authors: Plevka P., Battisti A.J., Junjhon J., Winkler D.C., Holdaway H.A., Keelapang P., Sittisombut N., Kuhn R.J., Steven A.C., Rossmann M.G.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-79957981824&partnerID=40&md5=7dd8bc033a4a8ccf1d9a0057ddaf70e4; http://cmuir.cmu.ac.th/handle/6653943832/3750
• Institution: Chiang Mai University

Flaviviruses assemble as fusion-incompetent immature particles and subsequently undergo conformational change leading to release of infectious virions. Flavivirus infections also produce combined mosaic particles. Here, using cryo-electron tomography, we report that mosaic particles of dengue virus...