Weight as predictors of clinical progression and treatment failure: Results from the TREAT Asia Pediatric HIV observational database

• Main Authors: Kariminia A., Durier N., Jourdain G., Saghayam S., Do C.V., Nguyen L.V., Hansudewechakul R., Lumbiganon P., Chokephaibulkit K., Truong K.H., Sirisanthana V., Ung V., Vonthanak S., Ananworanich J., Nik Yusoff N.K., Kurniati N., Azahar Razali K., Fong M.S., Nallusamy R., Wati D.K.
• Format: Article
• Language: English
• Published: Lippincott Williams and Wilkins 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84906085101&partnerID=40&md5=211fe68df10e2ee311a8a31c2dc6d8a4; http://cmuir.cmu.ac.th/handle/6653943832/37596
• Institution: Chiang Mai University

Objective: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). Methods: We used Cox regression to analyze data of a cohort of Asian children. Results: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score <-3 was associated with mortality (P < 0.001) independent of CD4% and <-2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. Conclusions: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings. © 2014 by Lippincott Williams & Wilkins.