Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses

Objective: The objective of this study was to compare the levels of fetal serum cardiac troponin T (cTnT), representing cardiac injury, and N-terminal pro-B-type natriuretic peptide (nt-proBNP), representing cardiac volume overload, between fetuses affected and not affected by hemoglobin (Hb) Bart&#...

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Main Authors: Tongprasert F., Srisupundit K., Luewan S., Tongsong T.
Format: Article
Language:English
Published: John Wiley and Sons Ltd 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84906842459&partnerID=40&md5=682f9b44ae93eec3bee6806fc12a8404
http://cmuir.cmu.ac.th/handle/6653943832/37603
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spelling th-cmuir.6653943832-376032014-12-09T05:50:38Z Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses Tongprasert F. Srisupundit K. Luewan S. Tongsong T. Objective: The objective of this study was to compare the levels of fetal serum cardiac troponin T (cTnT), representing cardiac injury, and N-terminal pro-B-type natriuretic peptide (nt-proBNP), representing cardiac volume overload, between fetuses affected and not affected by hemoglobin (Hb) Bart's disease, as well as between anemic and nonanemic fetuses. Methods: One hundred fourteen pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22weeks were recruited into the study. Fetal blood was collected to test for cTnT, nt-proBNP and Hb levels as well as Hb typing. Results: Serum nt-proBNP was significantly higher in Hb Bart's fetuses (24 cases) than in unaffected fetuses (63 cases), whereas cTnT was significantly lower in the affected group than in the unaffected group. The serum nt-proBNP levels significantly increased with the degree of fetal anemia; cTnT levels decreased in fetuses with high degree of anemia. Conclusions: At mid-pregnancy, nt-proBNP was significantly higher in fetuses with Hb Bart's disease than in nonanemic fetuses; cTnT was significantly lower in anemic than in normal fetuses. This study suggests that cardiomegaly from fetal anemia in early gestation is not associated with fetal cardiac injury or myocardial dysfunction but presents as cardiac volume overload from a compensatory process to maintain adequate tissue oxygenation. © 2014 John Wiley & Sons, Ltd. 2014-12-09T05:50:38Z 2014-12-09T05:50:38Z 2014 Article 01973851 10.1002/pd.4384 PRDID http://www.scopus.com/inward/record.url?eid=2-s2.0-84906842459&partnerID=40&md5=682f9b44ae93eec3bee6806fc12a8404 http://cmuir.cmu.ac.th/handle/6653943832/37603 English John Wiley and Sons Ltd
institution Chiang Mai University
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language English
description Objective: The objective of this study was to compare the levels of fetal serum cardiac troponin T (cTnT), representing cardiac injury, and N-terminal pro-B-type natriuretic peptide (nt-proBNP), representing cardiac volume overload, between fetuses affected and not affected by hemoglobin (Hb) Bart's disease, as well as between anemic and nonanemic fetuses. Methods: One hundred fourteen pregnancies at risk for fetal Hb Bart's disease scheduled for cordocentesis at 18 to 22weeks were recruited into the study. Fetal blood was collected to test for cTnT, nt-proBNP and Hb levels as well as Hb typing. Results: Serum nt-proBNP was significantly higher in Hb Bart's fetuses (24 cases) than in unaffected fetuses (63 cases), whereas cTnT was significantly lower in the affected group than in the unaffected group. The serum nt-proBNP levels significantly increased with the degree of fetal anemia; cTnT levels decreased in fetuses with high degree of anemia. Conclusions: At mid-pregnancy, nt-proBNP was significantly higher in fetuses with Hb Bart's disease than in nonanemic fetuses; cTnT was significantly lower in anemic than in normal fetuses. This study suggests that cardiomegaly from fetal anemia in early gestation is not associated with fetal cardiac injury or myocardial dysfunction but presents as cardiac volume overload from a compensatory process to maintain adequate tissue oxygenation. © 2014 John Wiley & Sons, Ltd.
format Article
author Tongprasert F.
Srisupundit K.
Luewan S.
Tongsong T.
spellingShingle Tongprasert F.
Srisupundit K.
Luewan S.
Tongsong T.
Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses
author_facet Tongprasert F.
Srisupundit K.
Luewan S.
Tongsong T.
author_sort Tongprasert F.
title Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses
title_short Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses
title_full Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses
title_fullStr Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses
title_full_unstemmed Comparison of cardiac troponin T and N-terminal pro-B-type natriuretic peptide between fetuses with hemoglobin Bart's disease and nonanemic fetuses
title_sort comparison of cardiac troponin t and n-terminal pro-b-type natriuretic peptide between fetuses with hemoglobin bart's disease and nonanemic fetuses
publisher John Wiley and Sons Ltd
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84906842459&partnerID=40&md5=682f9b44ae93eec3bee6806fc12a8404
http://cmuir.cmu.ac.th/handle/6653943832/37603
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