Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivativ...
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Elsevier
2014
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th-cmuir.6653943832-376382014-12-09T05:56:27Z Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma Pilapong C. Sitthichai S. Thongtem S. Thongtem T. We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivative polymer, specific capability of cancer-specific molecule (DNA-based EpCAM aptamer) and the imaging capability of magnetic iron oxide nanoparticles. Our proof-of-concept design demonstrates efficient in vitro MR imaging of the cancer cells, and enhanced delivery of an anticancer drug into the cancer cells with comparable treatment efficacy. © 2014 Elsevier B.V. 2014-12-09T05:56:27Z 2014-12-09T05:56:27Z 2014 Article 03785173 10.1016/j.ijpharm.2014.07.036 IJPHD http://www.scopus.com/inward/record.url?eid=2-s2.0-84905453309&partnerID=40&md5=919b04ff0bfed405a488d2c13d72a1b3 http://cmuir.cmu.ac.th/handle/6653943832/37638 English Elsevier |
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We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivative polymer, specific capability of cancer-specific molecule (DNA-based EpCAM aptamer) and the imaging capability of magnetic iron oxide nanoparticles. Our proof-of-concept design demonstrates efficient in vitro MR imaging of the cancer cells, and enhanced delivery of an anticancer drug into the cancer cells with comparable treatment efficacy. © 2014 Elsevier B.V. |
| format |
Article |
| author |
Pilapong C. Sitthichai S. Thongtem S. Thongtem T. |
| spellingShingle |
Pilapong C. Sitthichai S. Thongtem S. Thongtem T. Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| author_facet |
Pilapong C. Sitthichai S. Thongtem S. Thongtem T. |
| author_sort |
Pilapong C. |
| title |
Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| title_short |
Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| title_full |
Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| title_fullStr |
Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| title_full_unstemmed |
Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| title_sort |
smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma |
| publisher |
Elsevier |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-84905453309&partnerID=40&md5=919b04ff0bfed405a488d2c13d72a1b3 http://cmuir.cmu.ac.th/handle/6653943832/37638 |
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1681421383191494656 |