A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agents

• Main Authors: Phromnoi K., Reuter S., Sung B., Prasad S., Kannappan R., Yadav V.R., Chanmahasathien W., Limtrakul P., Aggarwal B.B.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-78751533767&partnerID=40&md5=d4cc0cd4e8d54d4876833095a9c8d83d; http://cmuir.cmu.ac.th/handle/6653943832/3790
• Institution: Chiang Mai University

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3′-dihydroxy-3,6,7,8,4′- pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB...