Decreased jaw bone density and osteoblastic insulin signaling in a model of obesity

• Main Authors: Pramojanee,S.N., Phimphilai,M., Kumphune,S., Chattipakorn,N., Chattipakorn,S.C.
• Format: Article
• Published: SAGE Publications Inc. 2015
• Subjects: Dentistry (all)
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84877850329&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/37993
• Institution: Chiang Mai University

Previous studies have demonstrated that decreased bone mass results from either the impairment of osteoblastic insulin signaling or obesity. Our previous study revealed that 12-week high-fat-diet (HFD) consumption caused obesity as well as peripheral and brain insulin resistance. However, the osteoblastic insulin resistance induced by HFD has not been elucidated. Therefore, we hypothesized that 12-week HFD rats exhibited not only peripheral insulin resistance but also osteoblastic insulin resistance, which leads to decreased jawbone quality. We found that the jawbones of rats fed a 12-week HFD exhibited increased osteoporosis. The osteoblastic cells isolated from HFD-fed rats exhibited the impairment of osteoblastic insulin signaling as well as reduction of cell proliferation and survival. In conclusion, this study demonstrated that insulin resistance induced by 12-week HFD impaired osteoblastic insulin signaling, osteoblast proliferation, and osteoblast survival and resulted in osteoporosis in the jawbone. © International & American Associations for Dental Research.