Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population

Background: Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim o...

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Main Authors: Laenoi,W., Uddin,M.J., Çinar,M.U., Groe-Brinkhaus,C., Tesfaye,D., Jónás,E.A., Scholz,A.M., Tholen,E., Looft,C., Wimmers,K., Phatsara,C., Juengst,H., Sauerwein,H., Mielenz,M., Schellander,K.
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Published: BioMed Central 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38023
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spelling th-cmuir.6653943832-380232015-06-16T04:14:30Z Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population Laenoi,W. Uddin,M.J. Çinar,M.U. Groe-Brinkhaus,C. Tesfaye,D. Jónás,E.A. Scholz,A.M. Tholen,E. Looft,C. Wimmers,K. Phatsara,C. Juengst,H. Sauerwein,H. Mielenz,M. Schellander,K. Medicine (all) Ecology, Evolution, Behavior and Systematics Genetics Animal Science and Zoology Background: Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs. Methods. Three hundred and ten F 2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software. Results: Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level. Conclusions: Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs. © 2011 Laenoi et al; licensee BioMed Central Ltd. 2015-06-16T04:14:29Z 2015-06-16T04:14:29Z 2011-12-01 Article 0999193X 2-s2.0-79960106302 10.1186/1297-9686-43-13 21418602 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79960106302&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38023 BioMed Central
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine (all)
Ecology, Evolution, Behavior and Systematics
Genetics
Animal Science and Zoology
spellingShingle Medicine (all)
Ecology, Evolution, Behavior and Systematics
Genetics
Animal Science and Zoology
Laenoi,W.
Uddin,M.J.
Çinar,M.U.
Groe-Brinkhaus,C.
Tesfaye,D.
Jónás,E.A.
Scholz,A.M.
Tholen,E.
Looft,C.
Wimmers,K.
Phatsara,C.
Juengst,H.
Sauerwein,H.
Mielenz,M.
Schellander,K.
Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
description Background: Leg weakness issues are a great concern for the pig breeding industry, especially with regard to animal welfare. Traits associated with leg weakness are partly influenced by the genetic background of the animals but the genetic basis of these traits is not yet fully understood. The aim of this study was to identify quantitative trait loci (QTL) affecting leg weakness in pigs. Methods. Three hundred and ten F 2 pigs from a Duroc × Pietrain resource population were genotyped using 82 genetic markers. Front and rear legs and feet scores were based on the standard scoring system. Osteochondrosis lesions were examined histologically at the head and the condylus medialis of the left femur and humerus. Bone mineral density, bone mineral content and bone mineral area were measured in the whole ulna and radius bones using dual energy X-ray absorptiometry. A line-cross model was applied to determine QTL regions associated with leg weakness using the QTL Express software. Results: Eleven QTL affecting leg weakness were identified on eight autosomes. All QTL reached the 5% chromosome-wide significance level. Three QTL were associated with osteochondrosis on the humerus end, two with the fore feet score and two with the rear leg score. QTL on SSC2 and SSC3 influencing bone mineral content and bone mineral density, respectively, reached the 5% genome-wide significance level. Conclusions: Our results confirm previous studies and provide information on new QTL associated with leg weakness in pigs. These results contribute towards a better understanding of the genetic background of leg weakness in pigs. © 2011 Laenoi et al; licensee BioMed Central Ltd.
format Article
author Laenoi,W.
Uddin,M.J.
Çinar,M.U.
Groe-Brinkhaus,C.
Tesfaye,D.
Jónás,E.A.
Scholz,A.M.
Tholen,E.
Looft,C.
Wimmers,K.
Phatsara,C.
Juengst,H.
Sauerwein,H.
Mielenz,M.
Schellander,K.
author_facet Laenoi,W.
Uddin,M.J.
Çinar,M.U.
Groe-Brinkhaus,C.
Tesfaye,D.
Jónás,E.A.
Scholz,A.M.
Tholen,E.
Looft,C.
Wimmers,K.
Phatsara,C.
Juengst,H.
Sauerwein,H.
Mielenz,M.
Schellander,K.
author_sort Laenoi,W.
title Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
title_short Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
title_full Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
title_fullStr Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
title_full_unstemmed Quantitative trait loci analysis for leg weakness-related traits in a Duroc × Pietrain crossbred population
title_sort quantitative trait loci analysis for leg weakness-related traits in a duroc × pietrain crossbred population
publisher BioMed Central
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=79960106302&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38023
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