Haplotypes of IL12B promoter polymorphisms condition susceptibility to severe malaria and functional changes in cytokine levels in Thai adults

• Main Authors: Phawong,C., Ouma,C., Tangteerawatana,P., Thongshoob,J., Were,T., Mahakunkijcharoen,Y., Wattanasirichaigoon,D., Perkins,D.J., Khusmith,S.
• Format: Article
• Published: Springer Verlag 2015
• Subjects: Immunology; Genetics
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77953153281&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38089
• Institution: Chiang Mai University

Polymorphic variability in immune response genes, such as IL12B, encoding the IL-12p40 subunit is associated with susceptibility to severe malaria in African populations. Since the role of genetic variation in conditioning severe malaria in Thai adults is largely unexplored, the functional associati...