Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: Reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus

• Main Authors: Dakeng,S., Duangmano,S., Jiratchariyakul,W., U-pratya,Y., Bögler,O., Patmasiriwat,P.
• Format: Article
• Published: Wiley-Liss Inc. 2015
• Subjects: Cell Biology; Molecular Biology; Biochemistry
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84055222706&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38091
• Institution: Chiang Mai University

The cucurbitacins are tetracyclic triterpenes found in plants of the family Cucurbitaceae. Cucurbitacins have been shown to have anti-cancer and anti-inflamatory activities. We investigated the anti-cancer activity of cucurbitacin B extracted from Thai medicinal plant Trichosanthes cucumerina Linn....