Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis

© 2015 Indian Society of Haematology & Transfusion Medicine Hemoglobin Constant Spring [Hb CS; α142, Term→Gln (TAA>CAA IN α2)] is often missed by routine laboratory testing, especially in subjects with co-inheritance of β-thalassemia or β-variants. We reported the case of a 1-year-old female...

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Main Authors: Pornprasert,S., Saoboontan,S., Wiengkum,T.
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Published: Springer India 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38136
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spelling th-cmuir.6653943832-381362015-06-16T07:38:29Z Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis Pornprasert,S. Saoboontan,S. Wiengkum,T. Hematology © 2015 Indian Society of Haematology & Transfusion Medicine Hemoglobin Constant Spring [Hb CS; α142, Term→Gln (TAA>CAA IN α2)] is often missed by routine laboratory testing, especially in subjects with co-inheritance of β-thalassemia or β-variants. We reported the case of a 1-year-old female with Hb H-CS disease who was born from a father with heterozygous of α-thalassemia-1 Southeast Asian type deletion and a mother with the combination of Hb CS and Hb E [β26 (B8) Glu→Lys, GAG>AAG] trait. A very tiny peak of Hb CS of the mother was easily ignored on the high performance liquid chromatography chromatogram while it was clearly seen on the capillary electrophoresis (CE) electrophoregram. Therefore, the CE is useful in screening for heterozygous Hb CS in a person with Hb E trait. This is of potential benefit for prevention of new cases of Hb H-CS disease. 2015-06-16T07:38:29Z 2015-06-16T07:38:29Z 2015-03-21 Article in Press 09714502 2-s2.0-84925435162 10.1007/s12288-015-0532-3 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925435162&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38136 Springer India
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Hematology
spellingShingle Hematology
Pornprasert,S.
Saoboontan,S.
Wiengkum,T.
Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis
description © 2015 Indian Society of Haematology & Transfusion Medicine Hemoglobin Constant Spring [Hb CS; α142, Term→Gln (TAA>CAA IN α2)] is often missed by routine laboratory testing, especially in subjects with co-inheritance of β-thalassemia or β-variants. We reported the case of a 1-year-old female with Hb H-CS disease who was born from a father with heterozygous of α-thalassemia-1 Southeast Asian type deletion and a mother with the combination of Hb CS and Hb E [β26 (B8) Glu→Lys, GAG>AAG] trait. A very tiny peak of Hb CS of the mother was easily ignored on the high performance liquid chromatography chromatogram while it was clearly seen on the capillary electrophoresis (CE) electrophoregram. Therefore, the CE is useful in screening for heterozygous Hb CS in a person with Hb E trait. This is of potential benefit for prevention of new cases of Hb H-CS disease.
format Article
author Pornprasert,S.
Saoboontan,S.
Wiengkum,T.
author_facet Pornprasert,S.
Saoboontan,S.
Wiengkum,T.
author_sort Pornprasert,S.
title Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis
title_short Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis
title_full Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis
title_fullStr Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis
title_full_unstemmed Hemoglobin Constant Spring (Hb CS) Missed by HPLC in an Hb E Trait Pregnancy Resulting in Hb H-CS Disease in a Thai Girl: Utility of Capillary Electrophoresis
title_sort hemoglobin constant spring (hb cs) missed by hplc in an hb e trait pregnancy resulting in hb h-cs disease in a thai girl: utility of capillary electrophoresis
publisher Springer India
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925435162&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38136
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