Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway

• Main Authors: Obchoei S., Sawanyawisuth K., Wongkham C., Kasinrerk W., Yao Q., Chen C., Wongkham S.
• Format: Article
• Published: Springer Netherlands 2015
• Subjects: Cancer Research
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84925465370&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38137
• Institution: Chiang Mai University

© 2014, International Society of Oncology and BioMarkers (ISOBM). Cyclophilin A (CypA) was shown to be upregulated in human cholangiocarcinoma (CCA) tissues. Suppression of intracellular CypA (inCypA) significantly reduces cell proliferation in vitro and tumor growth in nude mice. In the present stu...