Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice

© 2015 Informa UK, Ltd. Purpose: To investigate the biological effects of titanium (<sup>48</sup>Ti, one of the important heavy ions found in space) in the liver of exposed-mice. Materials and methods: We gave adult male CBA/CaJ mice a whole-body exposure to a total dose of 0, 0.1, 0.25...

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Main Authors: Jangiam,W., Tungjai,M., Rithidech,K.N.O.
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Published: Informa Healthcare 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38141
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spelling th-cmuir.6653943832-381412015-06-16T07:38:29Z Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice Jangiam,W. Tungjai,M. Rithidech,K.N.O. Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology © 2015 Informa UK, Ltd. Purpose: To investigate the biological effects of titanium (<sup>48</sup>Ti, one of the important heavy ions found in space) in the liver of exposed-mice. Materials and methods: We gave adult male CBA/CaJ mice a whole-body exposure to a total dose of 0, 0.1, 0.25 or 0.5 Gy of <sup>48</sup>Ti ions. The liver was collected at 1 week, 1 month, and 6 months post-irradiation (five mice per treatment-group at each harvest-time). Three biological endpoints were used for evaluating the effects of <sup>48</sup>Ti ions: Oxidative-stress, inflammatory responses, and DNA-methylation (5-methylcytosine and 5-hydroxymethylcytosine). Results: Our data clearly demonstrated dose-dependent increases in oxidative stress and inflammatory responses in the liver of exposed mice at all time-points (Analysis of Variance or ANOVA, p < 0.05). Significant dose-dependent increases in the levels of 5-methylcytosine were detected at 1 week and 1 month (ANOVA, p < 0.05). At 6 months post-irradiation, a significant increase in the level of 5-methylcytosine was found only in 0.5-Gy-<sup>48</sup>Ti-ion-exposed mice. In contrast, dose-dependent decreases in 5-hydroxymethylcytosine levels were found in the liver of exposed mice (ANOVA, p < 0.05) at all time-points. Conclusions: Chronic oxidative-stress, chronic inflammation, and persistent aberrant DNA-methylation occurred in the liver of <sup>48</sup>Ti-exposed mice. Hence, exposure to <sup>48</sup>Ti ions in space may pose health risks. 2015-06-16T07:38:29Z 2015-06-16T07:38:29Z 2015-01-01 Article 09553002 2-s2.0-84928615862 10.3109/09553002.2015.1001882 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928615862&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38141 Informa Healthcare
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Radiology, Nuclear Medicine and Imaging
Radiological and Ultrasound Technology
spellingShingle Radiology, Nuclear Medicine and Imaging
Radiological and Ultrasound Technology
Jangiam,W.
Tungjai,M.
Rithidech,K.N.O.
Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice
description © 2015 Informa UK, Ltd. Purpose: To investigate the biological effects of titanium (<sup>48</sup>Ti, one of the important heavy ions found in space) in the liver of exposed-mice. Materials and methods: We gave adult male CBA/CaJ mice a whole-body exposure to a total dose of 0, 0.1, 0.25 or 0.5 Gy of <sup>48</sup>Ti ions. The liver was collected at 1 week, 1 month, and 6 months post-irradiation (five mice per treatment-group at each harvest-time). Three biological endpoints were used for evaluating the effects of <sup>48</sup>Ti ions: Oxidative-stress, inflammatory responses, and DNA-methylation (5-methylcytosine and 5-hydroxymethylcytosine). Results: Our data clearly demonstrated dose-dependent increases in oxidative stress and inflammatory responses in the liver of exposed mice at all time-points (Analysis of Variance or ANOVA, p < 0.05). Significant dose-dependent increases in the levels of 5-methylcytosine were detected at 1 week and 1 month (ANOVA, p < 0.05). At 6 months post-irradiation, a significant increase in the level of 5-methylcytosine was found only in 0.5-Gy-<sup>48</sup>Ti-ion-exposed mice. In contrast, dose-dependent decreases in 5-hydroxymethylcytosine levels were found in the liver of exposed mice (ANOVA, p < 0.05) at all time-points. Conclusions: Chronic oxidative-stress, chronic inflammation, and persistent aberrant DNA-methylation occurred in the liver of <sup>48</sup>Ti-exposed mice. Hence, exposure to <sup>48</sup>Ti ions in space may pose health risks.
format Article
author Jangiam,W.
Tungjai,M.
Rithidech,K.N.O.
author_facet Jangiam,W.
Tungjai,M.
Rithidech,K.N.O.
author_sort Jangiam,W.
title Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice
title_short Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice
title_full Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice
title_fullStr Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice
title_full_unstemmed Induction of chronic oxidative stress, chronic inflammation and aberrant patterns of DNA methylation in the liver of titanium-exposed CBA/CaJ mice
title_sort induction of chronic oxidative stress, chronic inflammation and aberrant patterns of dna methylation in the liver of titanium-exposed cba/caj mice
publisher Informa Healthcare
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928615862&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38141
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