Connective tissue growth factor gene expression and decline in renal function in lupus nephritis

• Main Authors: Tachaudomdach,C., Kantachuvesiri,S., Changsirikulchai,S., Wimolluck,S., Pinpradap,K., Kitiyakara,C.
• Format: Article
• Published: Spandidos Publications 2015
• Subjects: Cancer Research; Immunology and Microbiology (miscellaneous); Medicine (all)
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84856987531&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38149
• Institution: Chiang Mai University

In lupus nephritis (LN), kidney inflammation may be followed by fibrosis and progressive decline in function. Transforming growth factor (TGF)-β is a notable mediator of fibrosis, but it has other beneficial roles, thus indicating a need for alternate therapeutic targets for inhibition of fibrosis....