Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study

• Main Authors: Gattermann,N., Finelli,C., Della Porta,M., Fénaux,P., Ganser,A.G., Guerci-Bresler,A., Schmid,M.L., Taylor,K.M., Vassilieff,D., Habr,D., Domokos,G., Roubert,B., Rose,C.S., Aǧaoǧlu,L., Alimena,G., Alonso,D., Amé,S., Angelucci,E., Arrizabalaga,B., Athanasiou-Metaxa,M., Augustson,B.M., Aydınok,Y., Baba,A.A., Baccarani,M., Beck,J.T., Béris,P.H., Beyne-Rauzy,O., Birgens,H.S., B́ordessoule,D., Borgna-Pignatti,C., Bosly,A.E., Bouabdallah,K., Bowden,D.K., Bowen,D.T., Bron,D.G., Cappellini,M.D.O., Capra,M.E.Z., Cartron,G., Cazzola,M., Chalkias,C., Chan,L., Chancharunee,S., Chapman,C.S., Charoenkwan,P., Chasapopoulou,E., Chèze,S., Chuansumrit,A., Cianciulli,P., Dauriac,C., Delforge,M., Dölken,G., Dombret,H., Duyster,J., Economopoulos,T.H., Ehninger,G.E., Elalfy,M.S., El Beshlawy,A., Enggaard,L., Fillet,G., Filosa,A., Forni,G.L., Galanello,R., Gastl,G.A., Giraudier,S., Goldfarb,A.W., Grigg,A.P., Gümrük,F.U., Ha,S.Y., Haase,D., Heinrich,B., Hertzberg,M.S., Ho,J., Hsu,H., Huang,S., Hunault-Berger,M., Inusa,B.P.D., Jaulmes,D., Jensen,J.M., Kattamis,A.C., Kilinç,Y., Kim,K., Kinsey,S.E., Kjeldsen,L., Koren,A., Lai,M., Lai,Y., Lee,J., Lee,K., Lee,S., Legros,L., Li,C., Li,Q., Lin,K., Linkesch,W.M., Lübbert,M., Lutz,D., Mohamed Thalha,A.J., Mufti,G.J., Muus,P.K., Nobile,F., Papadopoulos,N.T., Perrotta,S., Petrini,M.T., Pfeilstöcker,M., Piga,A.M., Poole,J.E., Porter,J.B., Pungolino,E.M., Quarta,G., Ravoet,C., Jolimont Lobbes,H.H., Remacha,A.F., Roy,L., Saglio,G.G., Sanz,G.F., Schmugge,M., Schots,H., Secchi,G., Seymour,J.F., Shah,F.T., Shah,H.N., Shen,Z., Slama,B., Sutcharitchan,P., Taher,A.T., Tamary,H., Tesch,H.J., Thein,S.L., Troncy,J., Villegas,A.M., Viprakasit,V., Wainwright,L., Waßmann,B., Wettervald,M., Will,A.M., Wörmann,B.J., Wright,J.G., Yeh,S., Yoon,S., Zoumbos,N.C., Zweegman,S.
• Format: Article
• Published: Elsevier Limited 2015
• Subjects: Cancer Research; Hematology; Oncology
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=77955268192&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38178
• Institution: Chiang Mai University

The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ∼50% were chelation-naïve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients w...