Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais

To examine whether there were gender differences in compositional changes of the coronary artery with aging, the authors investigated the gender difference in age-related changes of elements in the left coronary arteries of Thais by direct chemical analysis. After ordinary dissections by students at...

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Main Authors: Tohno,Y., Tohno,S., Mahakkanukrauh,P., Minami,T., Sinthubua,A., Suwannahoy,P., Ongkana,N., Laowatthanaphong,S., Azuma,C.
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Published: Humana Press 2015
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-381832015-06-16T07:46:31Z Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais Tohno,Y. Tohno,S. Mahakkanukrauh,P. Minami,T. Sinthubua,A. Suwannahoy,P. Ongkana,N. Laowatthanaphong,S. Azuma,C. Clinical Biochemistry Endocrinology, Diabetes and Metabolism Biochemistry (medical) Biochemistry Inorganic Chemistry To examine whether there were gender differences in compositional changes of the coronary artery with aging, the authors investigated the gender difference in age-related changes of elements in the left coronary arteries of Thais by direct chemical analysis. After ordinary dissections by students at Chiang Mai University were finished, the left coronary arteries were resected from Thai subjects. The Thai subjects consisted of 69 men and 34 women. The ages of the male subjects ranged from 25 to 87 years (average age=62.6±11.4 years) and of the female subjects from 24 to 86 years (average age=59.4±14.6 years). After incinerating the arteries with nitric acid and perchloric acid, the element content was determined by inductively coupled plasma-atomic emission spectrometry. The Ca and P contents tended to increase in the left coronary arteries of men with age, but the increases were not statistically significant. In the left coronary arteries of women, the Ca and P contents increased significantly and progressively with aging. In addition, the Na content increased significantly in the left coronary arteries of both men and women with aging. The differences in the average contents of Ca and P by age group were observed between the left coronary arteries of men and women. With Student's t test, significant gender differences in the average contents of Ca and P were found in both the 40s and the 70s. The Ca and P contents of the left coronary arteries in the 40s were significantly higher in men than in women. In contrast, the Ca and P contents in the 70s were significantly higher in women than in men. These results indicated that the accumulation of Ca and P in the left coronary arteries of Thais occurred at least 10 years earlier in men than in women, but a higher accumulation of Ca and P in old age occurred in the left coronary arteries of women compared with those of men. The present study revealed that there were significant gender differences inthe left coronary arteries with regard to the accumulation of Ca and P with aging. It is reasonable to presume that taking clinical findings into consideration, the gender differences in the left coronary arteries may result from hormonal and/or genetic factors rather than lifestyle factors. © Springer Science+Business Media, LLC 2011. 2015-06-16T07:46:31Z 2015-06-16T07:46:31Z 2011-12-01 Article 01634984 2-s2.0-84155172558 10.1007/s12011-011-9016-y 21547401 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84155172558&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38183 Humana Press
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Clinical Biochemistry
Endocrinology, Diabetes and Metabolism
Biochemistry (medical)
Biochemistry
Inorganic Chemistry
spellingShingle Clinical Biochemistry
Endocrinology, Diabetes and Metabolism
Biochemistry (medical)
Biochemistry
Inorganic Chemistry
Tohno,Y.
Tohno,S.
Mahakkanukrauh,P.
Minami,T.
Sinthubua,A.
Suwannahoy,P.
Ongkana,N.
Laowatthanaphong,S.
Azuma,C.
Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais
description To examine whether there were gender differences in compositional changes of the coronary artery with aging, the authors investigated the gender difference in age-related changes of elements in the left coronary arteries of Thais by direct chemical analysis. After ordinary dissections by students at Chiang Mai University were finished, the left coronary arteries were resected from Thai subjects. The Thai subjects consisted of 69 men and 34 women. The ages of the male subjects ranged from 25 to 87 years (average age=62.6±11.4 years) and of the female subjects from 24 to 86 years (average age=59.4±14.6 years). After incinerating the arteries with nitric acid and perchloric acid, the element content was determined by inductively coupled plasma-atomic emission spectrometry. The Ca and P contents tended to increase in the left coronary arteries of men with age, but the increases were not statistically significant. In the left coronary arteries of women, the Ca and P contents increased significantly and progressively with aging. In addition, the Na content increased significantly in the left coronary arteries of both men and women with aging. The differences in the average contents of Ca and P by age group were observed between the left coronary arteries of men and women. With Student's t test, significant gender differences in the average contents of Ca and P were found in both the 40s and the 70s. The Ca and P contents of the left coronary arteries in the 40s were significantly higher in men than in women. In contrast, the Ca and P contents in the 70s were significantly higher in women than in men. These results indicated that the accumulation of Ca and P in the left coronary arteries of Thais occurred at least 10 years earlier in men than in women, but a higher accumulation of Ca and P in old age occurred in the left coronary arteries of women compared with those of men. The present study revealed that there were significant gender differences inthe left coronary arteries with regard to the accumulation of Ca and P with aging. It is reasonable to presume that taking clinical findings into consideration, the gender differences in the left coronary arteries may result from hormonal and/or genetic factors rather than lifestyle factors. © Springer Science+Business Media, LLC 2011.
format Article
author Tohno,Y.
Tohno,S.
Mahakkanukrauh,P.
Minami,T.
Sinthubua,A.
Suwannahoy,P.
Ongkana,N.
Laowatthanaphong,S.
Azuma,C.
author_facet Tohno,Y.
Tohno,S.
Mahakkanukrauh,P.
Minami,T.
Sinthubua,A.
Suwannahoy,P.
Ongkana,N.
Laowatthanaphong,S.
Azuma,C.
author_sort Tohno,Y.
title Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais
title_short Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais
title_full Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais
title_fullStr Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais
title_full_unstemmed Gender difference in accumulation of calcium and phosphorus in the left coronary arteries of Thais
title_sort gender difference in accumulation of calcium and phosphorus in the left coronary arteries of thais
publisher Humana Press
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84155172558&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38183
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