Polyoxypregnane glycoside from Dregea volubilis extract inhibits IL-1β-induced expression of matrix metalloproteinase via activation of NF-κB in human chondrocytes

Polyoxypregnane glycoside from Dregea volubilis extract inhibits IL-1β-induced expression of matrix metalloproteinase via activation of NF-κB in human chondrocytes

Interleukin-1β (IL-1β) induces the expression of matrix metalloproteinases (MMPs) implicated in cartilage and joint degradation in osteoarthritis (OA) and rheumatoid arthritis (RA). Polyoxypregnane glycoside (PPG), active compound was identified from Dregea volubilis extract by chemical analysis, sh...

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Main Authors: Itthiarbha,A., Phitak,T., Sanyacharernkul,S., Pothacharoen,P., Pompimon,W., Kongtawelert,P.
Format: Article
Published: Society for In Vitro Biology 2015
Subjects:
Cell Biology
Developmental Biology
Clinical Biochemistry
Online Access:http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857234884&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38190
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Institution: Chiang Mai University

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http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857234884&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38190

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