Tuberculosis treatment with mobile-phone medication reminders in northern Thailand

Thailand's implementation of the Directly Observed Treatment, Short course (DOTS) strategy to increase tuberculosis (TB) control program efficacy has not achieved the World Health Organization (WHO) TB key targets. We defined two TB control models in the study. Patients in Model 1 were treated...

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Main Authors: Kunawararak,P., Pongpanich,S., Chantawong,S., Pokaew,P., Traisathit,P., Srithanaviboonchai,K., Plipat,T.
Format: Article
Published: Southeast Asian Ministers of Education Organisation 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38198
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-381982015-06-16T07:46:35Z Tuberculosis treatment with mobile-phone medication reminders in northern Thailand Kunawararak,P. Pongpanich,S. Chantawong,S. Pokaew,P. Traisathit,P. Srithanaviboonchai,K. Plipat,T. Infectious Diseases Public Health, Environmental and Occupational Health Thailand's implementation of the Directly Observed Treatment, Short course (DOTS) strategy to increase tuberculosis (TB) control program efficacy has not achieved the World Health Organization (WHO) TB key targets. We defined two TB control models in the study. Patients in Model 1 were treated with a conventional DOTS strategy and in Model 2, patients were treated the same as Model method 1 but were given a phone call reminder to take their medication. Multi-drug resistant tuberculosis (MDR-TB) and non-MDR-TB patients were randomized into either Model 1 or 2. Treatment outcomes were given as cure rates, completion rates, failure rates or success rates at 18 months in the MDR-TB group and 6 months in the non-MDR-TB group. The sputum conversion rate at 1 month were evaluated for both groups. In the MDR-TB group, the sputum conversion rate was 20% (95% CI 8-45) in Model 1 and 90% (95% CI 73-98) in Model 2 (p<0.001). In the non-MDR-TB group, the sputum conversion rate was 52% (95% CI 36-70) in Model 1 and 37% (95% CI 22-56) in Model 2 although the difference was not significant (p=0.221). The Model 2 success rates were significantly higher (73.7%, 96.7%) in both the MDR-TB and non-MDR-TB groups (p<0.001, p=0.047). The MDR-TB rate in northern Thailand decreased from 4.1% during April-September 2008 to 1.8% during April-September 2009. Further study of the association between implementation of Model 2 and MDR-TB incidence reduction needs to be carried out. 2015-06-16T07:46:35Z 2015-06-16T07:46:35Z 2011-12-01 Article 01251562 2-s2.0-84857663431 22299414 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857663431&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38198 Southeast Asian Ministers of Education Organisation
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Infectious Diseases
Public Health, Environmental and Occupational Health
spellingShingle Infectious Diseases
Public Health, Environmental and Occupational Health
Kunawararak,P.
Pongpanich,S.
Chantawong,S.
Pokaew,P.
Traisathit,P.
Srithanaviboonchai,K.
Plipat,T.
Tuberculosis treatment with mobile-phone medication reminders in northern Thailand
description Thailand's implementation of the Directly Observed Treatment, Short course (DOTS) strategy to increase tuberculosis (TB) control program efficacy has not achieved the World Health Organization (WHO) TB key targets. We defined two TB control models in the study. Patients in Model 1 were treated with a conventional DOTS strategy and in Model 2, patients were treated the same as Model method 1 but were given a phone call reminder to take their medication. Multi-drug resistant tuberculosis (MDR-TB) and non-MDR-TB patients were randomized into either Model 1 or 2. Treatment outcomes were given as cure rates, completion rates, failure rates or success rates at 18 months in the MDR-TB group and 6 months in the non-MDR-TB group. The sputum conversion rate at 1 month were evaluated for both groups. In the MDR-TB group, the sputum conversion rate was 20% (95% CI 8-45) in Model 1 and 90% (95% CI 73-98) in Model 2 (p<0.001). In the non-MDR-TB group, the sputum conversion rate was 52% (95% CI 36-70) in Model 1 and 37% (95% CI 22-56) in Model 2 although the difference was not significant (p=0.221). The Model 2 success rates were significantly higher (73.7%, 96.7%) in both the MDR-TB and non-MDR-TB groups (p<0.001, p=0.047). The MDR-TB rate in northern Thailand decreased from 4.1% during April-September 2008 to 1.8% during April-September 2009. Further study of the association between implementation of Model 2 and MDR-TB incidence reduction needs to be carried out.
format Article
author Kunawararak,P.
Pongpanich,S.
Chantawong,S.
Pokaew,P.
Traisathit,P.
Srithanaviboonchai,K.
Plipat,T.
author_facet Kunawararak,P.
Pongpanich,S.
Chantawong,S.
Pokaew,P.
Traisathit,P.
Srithanaviboonchai,K.
Plipat,T.
author_sort Kunawararak,P.
title Tuberculosis treatment with mobile-phone medication reminders in northern Thailand
title_short Tuberculosis treatment with mobile-phone medication reminders in northern Thailand
title_full Tuberculosis treatment with mobile-phone medication reminders in northern Thailand
title_fullStr Tuberculosis treatment with mobile-phone medication reminders in northern Thailand
title_full_unstemmed Tuberculosis treatment with mobile-phone medication reminders in northern Thailand
title_sort tuberculosis treatment with mobile-phone medication reminders in northern thailand
publisher Southeast Asian Ministers of Education Organisation
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84857663431&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38198
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