Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy

This study was undertaken to compare the survival rates of stage IB 1 versus stage IB 2 cervical cancer patients and to evaluate the prognostic factors after treatment primarily with radical hysterectomy and pelvic lymphadenectomy (RHPL). Patients with stage IB cervical cancer undergoing primary RHP...

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Main Authors: Srisomboon,J., Kietpeerakool,C., Suprasert,P., Manopanya,M., Siriaree,S., Charoenkwan,K., Cheewakriangkrai,C., Sae-Teng,C.T.
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Published: Asian Pacific Organization for Cancer Prevention 2015
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Online Access:http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864360542&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38218
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-382182015-06-16T07:46:38Z Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy Srisomboon,J. Kietpeerakool,C. Suprasert,P. Manopanya,M. Siriaree,S. Charoenkwan,K. Cheewakriangkrai,C. Sae-Teng,C.T. Cancer Research Oncology Epidemiology Public Health, Environmental and Occupational Health This study was undertaken to compare the survival rates of stage IB 1 versus stage IB 2 cervical cancer patients and to evaluate the prognostic factors after treatment primarily with radical hysterectomy and pelvic lymphadenectomy (RHPL). Patients with stage IB cervical cancer undergoing primary RHPL at Chiang Mai University Hospital between January 2002 and December 2009 were evaluated for survival and recurrence. Clinicopathological variables were analyzed to identify the prognostic factors affecting the survival of the patients. During the study period, RHPL was performed on 570 stage IB 1 and 110 stage IB 2 cervical cancer patients. With a median follow-up of 48 months, the 5-year disease-free survivals were 98.1% and 82.8% respectively (p < 0.001). Multivariate analysis identified four significant prognostic factors affecting survival including sub-staging, non-squamous cell carcinoma histology, lymph node metastasis and the presence of lymph-vascular space invasion. In conclusion, with a primary radical hysterectomy, stage IB 1 cervical cancer patients have a significantly better survival rate than those with stage IB 2. Significant prognostic factors for stage IB cervical cancer include tumor histology, nodal status, and the presence of lymph-vascular space invasion. 2015-06-16T07:46:38Z 2015-06-16T07:46:38Z 2011-12-01 Article 15137368 2-s2.0-84864360542 22126559 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864360542&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38218 Asian Pacific Organization for Cancer Prevention
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
spellingShingle Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
Srisomboon,J.
Kietpeerakool,C.
Suprasert,P.
Manopanya,M.
Siriaree,S.
Charoenkwan,K.
Cheewakriangkrai,C.
Sae-Teng,C.T.
Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy
description This study was undertaken to compare the survival rates of stage IB 1 versus stage IB 2 cervical cancer patients and to evaluate the prognostic factors after treatment primarily with radical hysterectomy and pelvic lymphadenectomy (RHPL). Patients with stage IB cervical cancer undergoing primary RHPL at Chiang Mai University Hospital between January 2002 and December 2009 were evaluated for survival and recurrence. Clinicopathological variables were analyzed to identify the prognostic factors affecting the survival of the patients. During the study period, RHPL was performed on 570 stage IB 1 and 110 stage IB 2 cervical cancer patients. With a median follow-up of 48 months, the 5-year disease-free survivals were 98.1% and 82.8% respectively (p < 0.001). Multivariate analysis identified four significant prognostic factors affecting survival including sub-staging, non-squamous cell carcinoma histology, lymph node metastasis and the presence of lymph-vascular space invasion. In conclusion, with a primary radical hysterectomy, stage IB 1 cervical cancer patients have a significantly better survival rate than those with stage IB 2. Significant prognostic factors for stage IB cervical cancer include tumor histology, nodal status, and the presence of lymph-vascular space invasion.
format Article
author Srisomboon,J.
Kietpeerakool,C.
Suprasert,P.
Manopanya,M.
Siriaree,S.
Charoenkwan,K.
Cheewakriangkrai,C.
Sae-Teng,C.T.
author_facet Srisomboon,J.
Kietpeerakool,C.
Suprasert,P.
Manopanya,M.
Siriaree,S.
Charoenkwan,K.
Cheewakriangkrai,C.
Sae-Teng,C.T.
author_sort Srisomboon,J.
title Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy
title_short Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy
title_full Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy
title_fullStr Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy
title_full_unstemmed Survival and prognostic factors comparing stage IB 1 versus stage IB 2 cervical cancer treated with primary radical hysterectomy
title_sort survival and prognostic factors comparing stage ib 1 versus stage ib 2 cervical cancer treated with primary radical hysterectomy
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864360542&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38218
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