Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda

The ethanolic extract of Boesenbergia rotunda (L.) Mansf. was studied for its wound-healing potential. Since wound healing is interrelated with microbial infection and reactive oxygen species (ROS), this study was conducted to evaluate the antimicrobial and antioxidant activity of B. rotunda. The an...

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Main Authors: Jitvaropas,R., Saenthaweesuk,S., Somparn,N., Thuppia,A., Sireeratawong,S., Phoolcharoen,W.
Format: Article
Published: Natural Product Communications 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38222
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spelling th-cmuir.6653943832-382222015-06-16T07:46:38Z Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda Jitvaropas,R. Saenthaweesuk,S. Somparn,N. Thuppia,A. Sireeratawong,S. Phoolcharoen,W. Plant Science Drug Discovery Pharmacology Complementary and Alternative Medicine The ethanolic extract of Boesenbergia rotunda (L.) Mansf. was studied for its wound-healing potential. Since wound healing is interrelated with microbial infection and reactive oxygen species (ROS), this study was conducted to evaluate the antimicrobial and antioxidant activity of B. rotunda. The antimicrobial activity of B. rotunda was studied against six bacterial and two yeast strains using disc diffusion, minimum inhibitory concentration (MIC), and minimum microbicidal concentration (MMC). The B. rotunda extract displayed potential antimicrobial and antifungal activities by inhibiting the Gram-positive bacteria Staphylococcus aureus (ATCC 25923), S. epidermidis, and Bacillus subtilis (ATCC 6633), and the yeasts Candida albicans (ATCC 10231), and Saccharomyces cerevisiae. MIC and MMC values varied from 0.04 to 25 mg/mL and from 0.16 to 25 mg/mL, respectively. The antioxidant activity of B. rotunda was evaluated by measuring the Ferric Reducing/Antioxidant Power (FRAP) and DPPH free radical scavenging activity. The FRAP and DPPH values were 22.2 μM /ug and 76.3 mg/mL, respectively. In the wound-healing studies, the topical application of the B. rotunda extract indicated a significantly increased percentage of wound contraction on day 12 compared with the control group. Histological studies showed the complete epidermis and found collagen fibers and hair follicles in the dermis. The results of the present study support the continued and expanded utilization of B. rotunda in Thai folk medicine. 2015-06-16T07:46:38Z 2015-06-16T07:46:38Z 2012-08-13 Article 1934578X 2-s2.0-84864711697 22908579 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864711697&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38222 Natural Product Communications
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Plant Science
Drug Discovery
Pharmacology
Complementary and Alternative Medicine
spellingShingle Plant Science
Drug Discovery
Pharmacology
Complementary and Alternative Medicine
Jitvaropas,R.
Saenthaweesuk,S.
Somparn,N.
Thuppia,A.
Sireeratawong,S.
Phoolcharoen,W.
Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda
description The ethanolic extract of Boesenbergia rotunda (L.) Mansf. was studied for its wound-healing potential. Since wound healing is interrelated with microbial infection and reactive oxygen species (ROS), this study was conducted to evaluate the antimicrobial and antioxidant activity of B. rotunda. The antimicrobial activity of B. rotunda was studied against six bacterial and two yeast strains using disc diffusion, minimum inhibitory concentration (MIC), and minimum microbicidal concentration (MMC). The B. rotunda extract displayed potential antimicrobial and antifungal activities by inhibiting the Gram-positive bacteria Staphylococcus aureus (ATCC 25923), S. epidermidis, and Bacillus subtilis (ATCC 6633), and the yeasts Candida albicans (ATCC 10231), and Saccharomyces cerevisiae. MIC and MMC values varied from 0.04 to 25 mg/mL and from 0.16 to 25 mg/mL, respectively. The antioxidant activity of B. rotunda was evaluated by measuring the Ferric Reducing/Antioxidant Power (FRAP) and DPPH free radical scavenging activity. The FRAP and DPPH values were 22.2 μM /ug and 76.3 mg/mL, respectively. In the wound-healing studies, the topical application of the B. rotunda extract indicated a significantly increased percentage of wound contraction on day 12 compared with the control group. Histological studies showed the complete epidermis and found collagen fibers and hair follicles in the dermis. The results of the present study support the continued and expanded utilization of B. rotunda in Thai folk medicine.
format Article
author Jitvaropas,R.
Saenthaweesuk,S.
Somparn,N.
Thuppia,A.
Sireeratawong,S.
Phoolcharoen,W.
author_facet Jitvaropas,R.
Saenthaweesuk,S.
Somparn,N.
Thuppia,A.
Sireeratawong,S.
Phoolcharoen,W.
author_sort Jitvaropas,R.
title Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda
title_short Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda
title_full Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda
title_fullStr Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda
title_full_unstemmed Antioxidant, antimicrobial and wound healing activities of Boesenbergia rotunda
title_sort antioxidant, antimicrobial and wound healing activities of boesenbergia rotunda
publisher Natural Product Communications
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84864711697&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38222
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