Beneficial effects of thai purple sticky rice supplement in streptozotocin induced diabetic rats

• Main Authors: Apichai,S., Pongchaidecha,A., Kaeapai,W., Jitprawet,N., Lailerd,N.
• Format: Article
• Published: Chiang Mai University 2015
• Subjects: Multidisciplinary
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84872244160&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38246
• Institution: Chiang Mai University

This study was conducted to evaluate antihyperglycemic and hypolipidemic effects of anthocyanin-rich bran from Thai purple sticky rice in streptozotocin (STZ) induced diabetic rats. Male Wistar rats were divided into five groups: normal rats control (NC), normal rats which received purple rice bran (NR), diabetic rats control (DMC), diabetic rats which received purple rice bran (DMR), and diabetic rats which treated with insulin (DMI). NR and DMR groups received normal diet with purple rice bran at dose 50 g/kg diet. Insulin (20 Units/kg BW) was injected (intraperitoneally) to DMI rats throughout the experimental period. After STZ-induced diabetic condition had been established, 8 weeks treatment with purple rice bran or insulin injection successfully decreased plasma glucose, triglyceride (TG), and free fatty acid (FFA) levels but did not change plasma cholesterol level when compared with DMC. Interestingly, no change in plasma glucose level was noted in NR when compared with NC. At the end of the study, an oral glucose tolerance test (OGTT) was performed to determine the insulin sensitivity. The results demonstrated that purple rice bran and insulin treatment significantly decreased TAUCg, BAUCg, and IAUCg from OGTT compared to DMC. These findings indicated that purple rice bran profoundly improved the whole body insulin sensitivity. Based on these results, we found that the anthocyanin-rich bran from purple sticky rice has beneficial effects in STZ-induced diabetic rats. This purple rice bran may be a good candidate for promising neutraceutical treatment for the diabetic management. However, the mechanisms of antihyperglycemic and hypolipidemic actions of the purple rice bran need to be further investigated.