Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix

Objectives: To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA). Methods: Formalin-fixed, paraffinembedded tissue of cervical NECA patients with known HPV18 infection and clinicopathologic da...

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Main Authors: Siriaunkgul S., Utaipat U., Suwiwat S., Settakorn J., Sukpan K., Srisomboon J., Khunamornpong S.
Format: Article
Published: Asian Pacific Organization for Cancer Prevention 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38258
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spelling th-cmuir.6653943832-382582015-06-16T07:46:46Z Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix Siriaunkgul S. Utaipat U. Suwiwat S. Settakorn J. Sukpan K. Srisomboon J. Khunamornpong S. Cancer Research Oncology Epidemiology Public Health, Environmental and Occupational Health Objectives: To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA). Methods: Formalin-fixed, paraffinembedded tissue of cervical NECA patients with known HPV18 infection and clinicopathologic data including follow-up results were collected. The HPV18 DNA load was assessed with quantitative PCR targeting the HPV18 E6E7 region. Results: Twenty-one patients with early-stage (IB-IIA) cervical NECA were identified. HPV18 DNA viral load ranged from 0.83 to 55,174 copies/cell (median 5.90). Disease progression, observed in 10 cases (48%), was not significantly associated with any clinicopathologic variables. However, the group of patients with progressive disease tended to have a higher rate of pelvic lymph node metastasis (50% versus 9%, p=0.063) and a lower median value of HPV18 DNA viral load (4.37 versus 8.17 copies/cell, p=0.198) compared to the non-recurrent group. When stratified by a cut-off viral load value of 5.00 copies/cell, the group of patients with viral load ≤5.00 copies/cell had a significantly shorter disease-free survival than the group with viral load >5.00 copies/cell (p=0.028). The group with a lower viral load also tended to have a higher rate of disease progression (75% versus 31%, p=0.080). No significant difference in the other clinicopathologic variables between the lower and higher viral load groups was identified. Conclusion: HPV18 DNA viral load may have a prognostic value in patients with early-stage NECA of the cervix. A low viral load may be predictive of shortened disease-free survival in these patients. 2015-06-16T07:46:46Z 2015-06-16T07:46:46Z 2012-12-01 Article 15137368 2-s2.0-84873596293 10.7314/APJCP.2012.13.7.3281 22994748 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873596293&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38258 Asian Pacific Organization for Cancer Prevention
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
spellingShingle Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
Siriaunkgul S.
Utaipat U.
Suwiwat S.
Settakorn J.
Sukpan K.
Srisomboon J.
Khunamornpong S.
Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
description Objectives: To evaluate the clinicopathologic correlation and prognostic value of HPV18 DNA viral load in patients with early-stage cervical neuroendocrine carcinoma (NECA). Methods: Formalin-fixed, paraffinembedded tissue of cervical NECA patients with known HPV18 infection and clinicopathologic data including follow-up results were collected. The HPV18 DNA load was assessed with quantitative PCR targeting the HPV18 E6E7 region. Results: Twenty-one patients with early-stage (IB-IIA) cervical NECA were identified. HPV18 DNA viral load ranged from 0.83 to 55,174 copies/cell (median 5.90). Disease progression, observed in 10 cases (48%), was not significantly associated with any clinicopathologic variables. However, the group of patients with progressive disease tended to have a higher rate of pelvic lymph node metastasis (50% versus 9%, p=0.063) and a lower median value of HPV18 DNA viral load (4.37 versus 8.17 copies/cell, p=0.198) compared to the non-recurrent group. When stratified by a cut-off viral load value of 5.00 copies/cell, the group of patients with viral load ≤5.00 copies/cell had a significantly shorter disease-free survival than the group with viral load >5.00 copies/cell (p=0.028). The group with a lower viral load also tended to have a higher rate of disease progression (75% versus 31%, p=0.080). No significant difference in the other clinicopathologic variables between the lower and higher viral load groups was identified. Conclusion: HPV18 DNA viral load may have a prognostic value in patients with early-stage NECA of the cervix. A low viral load may be predictive of shortened disease-free survival in these patients.
format Article
author Siriaunkgul S.
Utaipat U.
Suwiwat S.
Settakorn J.
Sukpan K.
Srisomboon J.
Khunamornpong S.
author_facet Siriaunkgul S.
Utaipat U.
Suwiwat S.
Settakorn J.
Sukpan K.
Srisomboon J.
Khunamornpong S.
author_sort Siriaunkgul S.
title Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
title_short Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
title_full Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
title_fullStr Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
title_full_unstemmed Prognostic value of HPV18 DNA viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
title_sort prognostic value of hpv18 dna viral load in patients with early-stage neuroendocrine carcinoma of the uterine cervix
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873596293&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38258
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