Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD

This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU...

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Main Authors: Zhou,J., Tanuma,J., Chaiwarith,R., Lee,C., Law,M., Kumarasamy,N., Phanuphak,P.P., Chen,Y., Kiertiburanakul,S., Zhang,F., Vonthanak,S., Ditangco,R.A., Pujari,S.N., Choi,J., Parwati Merati,T., Yunihastuti,E., Li,P., Kamarulzaman,A.B., Nguyen,V.K., Thuy Pham,T.T., Lim,P.
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Published: Hindawi Publishing Corporation 2015
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spelling th-cmuir.6653943832-382592015-06-16T07:46:46Z Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD Zhou,J. Tanuma,J. Chaiwarith,R. Lee,C. Law,M. Kumarasamy,N. Phanuphak,P.P. Chen,Y. Kiertiburanakul,S. Zhang,F. Vonthanak,S. Ditangco,R.A. Pujari,S.N. Choi,J. Parwati Merati,T. Yunihastuti,E. Li,P. Kamarulzaman,A.B. Nguyen,V.K. Thuy Pham,T.T. Lim,P. Immunology and Allergy Infectious Diseases Public Health, Environmental and Occupational Health Dermatology This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU were then categorised into permanently LTFU (never returned) and temporary LTFU (re-entered later), and these groups compared. A total of 3626 patients were included (71% male). No clinic visits for 180 days was the best-performing LTFU definition (sensitivity 90.6%, specificity 92.3%). During 7697 person-years of follow-up, 1648 episodes of LFTU were recorded (21.4 per 100-person-years). Patients LFTU were younger (P = 0.002), had HIV viral load ≥500 copies/mL or missing (P = 0.021), had shorter history of HIV infection (P = 0.048), and received no, single- or double-antiretroviral therapy, or a triple-drug regimen containing a protease inhibitor (P < 0.001). 48% of patients LTFU never returned. These patients were more likely to have low or missing haemoglobin (P < 0.001), missing recent HIV viral load (P < 0.001), negative hepatitis C test (P = 0.025), and previous temporary LTFU episodes (P < 0.001). Our analyses suggest that patients not seen at a clinic for 180 days are at high risk of permanent LTFU, and should be aggressively traced. © 2012 Jialun Zhou et al. 2015-06-16T07:46:46Z 2015-06-16T07:46:46Z 2012-12-01 Article 20901240 2-s2.0-84873877453 10.1155/2012/375217 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873877453&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38259 Hindawi Publishing Corporation
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Immunology and Allergy
Infectious Diseases
Public Health, Environmental and Occupational Health
Dermatology
spellingShingle Immunology and Allergy
Infectious Diseases
Public Health, Environmental and Occupational Health
Dermatology
Zhou,J.
Tanuma,J.
Chaiwarith,R.
Lee,C.
Law,M.
Kumarasamy,N.
Phanuphak,P.P.
Chen,Y.
Kiertiburanakul,S.
Zhang,F.
Vonthanak,S.
Ditangco,R.A.
Pujari,S.N.
Choi,J.
Parwati Merati,T.
Yunihastuti,E.
Li,P.
Kamarulzaman,A.B.
Nguyen,V.K.
Thuy Pham,T.T.
Lim,P.
Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
description This study examined characteristics of HIV-infected patients in the TREAT Asia HIV Observational Database who were lost to follow-up (LTFU) from treatment and care. Time from last clinic visit to 31 March 2009 was analysed to determine the interval that best classified LTFU. Patients defined as LTFU were then categorised into permanently LTFU (never returned) and temporary LTFU (re-entered later), and these groups compared. A total of 3626 patients were included (71% male). No clinic visits for 180 days was the best-performing LTFU definition (sensitivity 90.6%, specificity 92.3%). During 7697 person-years of follow-up, 1648 episodes of LFTU were recorded (21.4 per 100-person-years). Patients LFTU were younger (P = 0.002), had HIV viral load ≥500 copies/mL or missing (P = 0.021), had shorter history of HIV infection (P = 0.048), and received no, single- or double-antiretroviral therapy, or a triple-drug regimen containing a protease inhibitor (P < 0.001). 48% of patients LTFU never returned. These patients were more likely to have low or missing haemoglobin (P < 0.001), missing recent HIV viral load (P < 0.001), negative hepatitis C test (P = 0.025), and previous temporary LTFU episodes (P < 0.001). Our analyses suggest that patients not seen at a clinic for 180 days are at high risk of permanent LTFU, and should be aggressively traced. © 2012 Jialun Zhou et al.
format Article
author Zhou,J.
Tanuma,J.
Chaiwarith,R.
Lee,C.
Law,M.
Kumarasamy,N.
Phanuphak,P.P.
Chen,Y.
Kiertiburanakul,S.
Zhang,F.
Vonthanak,S.
Ditangco,R.A.
Pujari,S.N.
Choi,J.
Parwati Merati,T.
Yunihastuti,E.
Li,P.
Kamarulzaman,A.B.
Nguyen,V.K.
Thuy Pham,T.T.
Lim,P.
author_facet Zhou,J.
Tanuma,J.
Chaiwarith,R.
Lee,C.
Law,M.
Kumarasamy,N.
Phanuphak,P.P.
Chen,Y.
Kiertiburanakul,S.
Zhang,F.
Vonthanak,S.
Ditangco,R.A.
Pujari,S.N.
Choi,J.
Parwati Merati,T.
Yunihastuti,E.
Li,P.
Kamarulzaman,A.B.
Nguyen,V.K.
Thuy Pham,T.T.
Lim,P.
author_sort Zhou,J.
title Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
title_short Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
title_full Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
title_fullStr Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
title_full_unstemmed Loss to followup in HIV-infected patients from Asia-pacific region: Results from TAHOD
title_sort loss to followup in hiv-infected patients from asia-pacific region: results from tahod
publisher Hindawi Publishing Corporation
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84873877453&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38259
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