Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits

The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in...

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Main Authors: Suwannaloet W., Laupattarakasem W., Sukon P., Ong-Chai S., Laupattarakasem P.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-84861083462&partnerID=40&md5=5cde0a2d11d3eef4cb71883f03e8ede1
http://cmuir.cmu.ac.th/handle/6653943832/3828
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-38282014-08-30T02:35:22Z Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits Suwannaloet W. Laupattarakasem W. Sukon P. Ong-Chai S. Laupattarakasem P. The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA. © 2012 Wanwisa Suwannaloet et al. 2014-08-30T02:35:22Z 2014-08-30T02:35:22Z 2012 Article 1537744X 10.1100/2012/310745 http://www.scopus.com/inward/record.url?eid=2-s2.0-84861083462&partnerID=40&md5=5cde0a2d11d3eef4cb71883f03e8ede1 http://cmuir.cmu.ac.th/handle/6653943832/3828 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA. © 2012 Wanwisa Suwannaloet et al.
format Article
author Suwannaloet W.
Laupattarakasem W.
Sukon P.
Ong-Chai S.
Laupattarakasem P.
spellingShingle Suwannaloet W.
Laupattarakasem W.
Sukon P.
Ong-Chai S.
Laupattarakasem P.
Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
author_facet Suwannaloet W.
Laupattarakasem W.
Sukon P.
Ong-Chai S.
Laupattarakasem P.
author_sort Suwannaloet W.
title Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
title_short Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
title_full Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
title_fullStr Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
title_full_unstemmed Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
title_sort combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-84861083462&partnerID=40&md5=5cde0a2d11d3eef4cb71883f03e8ede1
http://cmuir.cmu.ac.th/handle/6653943832/3828
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