Active compound of Zingiber cassumunar Roxb. down-regulates the expression of genes involved in joint erosion in a human synovial fibroblast cell line.

• Main Authors: Chaiwongsa R., Ongchai S., Boonsing P., Kongtawelert P., Panthong A., Reutrakul V.
• Format: Article
• Published: African Ethnomedicines Network 2015
• Subjects: Drug Discovery; Medicine (all); Complementary and Alternative Medicine
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84897921786&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38283
• Institution: Chiang Mai University

Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovium. It is involved in up-regulation of pro-inflammatory cytokines and matrix metalloproteinases (MMPs), resulting in joint inflammation and erosion. Zingiber cassumunar Roxb. has long been used to reduce joint pain and inflamma...