Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan

• Main Authors: Okitsu,S., Khamrin,P., Thongprachum,A., Nishimura,S., Kalesaran,A.F.C., Takanashi,S., Shimizu,H., Hayakawa,S., Mizuguchi,M., Ushijima,H.
• Format: Article
• Published: Elsevier 2015
• Subjects: Microbiology; Ecology, Evolution, Behavior and Systematics; Molecular Biology; Genetics; Infectious Diseases; Microbiology (medical)
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907693118&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38313
• Institution: Chiang Mai University

© 2014 Elsevier B.V. Human cosavirus (HCoSV) is a genus recently identified in the family Picornaviridae, which includes important pathogens in human health. The pathogenicity of HCoSV remains unclear. This study reports that an HCoSV strain, 10928/2012/JPN, was identified and collected from the stool sample of a child with acute gastroenteritis in Japan, with the detection rate of 0.16%. The patient was not co-infected with other common diarrhea-causal viruses, suggesting HCoSV as a causal pathogen in this pediatric patient. Phylogenetic and sequence analyses exhibited that the virus strain was classified as a new genotype in HCoSV A species, and this study is first to detect HCoSV in a clinical specimen collected in Japan. These results showed that surveillance of HCoSV is important for detecting viral agents in children with diarrhea, despite being the low detection rate.