Possible roles of insulin signaling in osteoblasts

© 2014 Informa Healthcare USA, Inc. Insulin and its downstream signaling pathway are indispensable for postnatal bone growth and turnover by having influence on both osteoblast and osteoclast development. Insulin signaling regulates both bone formation by osteoblasts and bone resorption by osteoclas...

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Main Authors: Pramojanee,S.N., Phimphilai,M., Chattipakorn,N., Chattipakorn,S.C.
Format: Review
Published: Informa Healthcare 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38339
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-383392015-06-16T07:47:01Z Possible roles of insulin signaling in osteoblasts Pramojanee,S.N. Phimphilai,M. Chattipakorn,N. Chattipakorn,S.C. Endocrinology © 2014 Informa Healthcare USA, Inc. Insulin and its downstream signaling pathway are indispensable for postnatal bone growth and turnover by having influence on both osteoblast and osteoclast development. Insulin signaling regulates both bone formation by osteoblasts and bone resorption by osteoclasts; however, the regulation occurs mainly through the insulin signaling pathway within osteoblasts. An impairment of osteoblastic insulin signaling leads to an impaired bone quality by affecting osteoblast proliferation, differentiation and survival. The insulin signaling pathway and MAPK and PI3K/Akt pathways play pivotal roles in the differentiation, function and survival of bone cells. Current evidence suggests that osteoblastic insulin signaling not only modulates bone growth and turnover but is also required for energy metabolism. Several mice models with impaired insulin signaling exhibited both bone and metabolic phenotypes, including symptoms of low bone mass, obesity, glucose intolerance and insulin resistance. In this review, we discuss the key findings that suggest a pivotal role of osteoblastic insulin signaling in both bone and energy metabolism. 2015-06-16T07:47:01Z 2015-06-16T07:47:01Z 2014-01-01 Review 07435800 2-s2.0-84911478017 10.3109/07435800.2013.879168 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84911478017&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38339 Informa Healthcare
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Endocrinology
spellingShingle Endocrinology
Pramojanee,S.N.
Phimphilai,M.
Chattipakorn,N.
Chattipakorn,S.C.
Possible roles of insulin signaling in osteoblasts
description © 2014 Informa Healthcare USA, Inc. Insulin and its downstream signaling pathway are indispensable for postnatal bone growth and turnover by having influence on both osteoblast and osteoclast development. Insulin signaling regulates both bone formation by osteoblasts and bone resorption by osteoclasts; however, the regulation occurs mainly through the insulin signaling pathway within osteoblasts. An impairment of osteoblastic insulin signaling leads to an impaired bone quality by affecting osteoblast proliferation, differentiation and survival. The insulin signaling pathway and MAPK and PI3K/Akt pathways play pivotal roles in the differentiation, function and survival of bone cells. Current evidence suggests that osteoblastic insulin signaling not only modulates bone growth and turnover but is also required for energy metabolism. Several mice models with impaired insulin signaling exhibited both bone and metabolic phenotypes, including symptoms of low bone mass, obesity, glucose intolerance and insulin resistance. In this review, we discuss the key findings that suggest a pivotal role of osteoblastic insulin signaling in both bone and energy metabolism.
format Review
author Pramojanee,S.N.
Phimphilai,M.
Chattipakorn,N.
Chattipakorn,S.C.
author_facet Pramojanee,S.N.
Phimphilai,M.
Chattipakorn,N.
Chattipakorn,S.C.
author_sort Pramojanee,S.N.
title Possible roles of insulin signaling in osteoblasts
title_short Possible roles of insulin signaling in osteoblasts
title_full Possible roles of insulin signaling in osteoblasts
title_fullStr Possible roles of insulin signaling in osteoblasts
title_full_unstemmed Possible roles of insulin signaling in osteoblasts
title_sort possible roles of insulin signaling in osteoblasts
publisher Informa Healthcare
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84911478017&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38339
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