Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center

To assess survival outcomes in a retrospective study, recurrent epithelial ovarian cancer patients were divided into three groups according to the platinum free interval as follows: platinum refractory that included the patients with tumor progression during treatment; platinum resistant and platinu...

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Main Authors: Jansaka,N., Suprasert,P.
Format: Article
Published: Asian Pacific Organization for Cancer Prevention 2015
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http://cmuir.cmu.ac.th/handle/6653943832/38392
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spelling th-cmuir.6653943832-383922015-06-16T07:47:08Z Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center Jansaka,N. Suprasert,P. Cancer Research Oncology Epidemiology Public Health, Environmental and Occupational Health To assess survival outcomes in a retrospective study, recurrent epithelial ovarian cancer patients were divided into three groups according to the platinum free interval as follows: platinum refractory that included the patients with tumor progression during treatment; platinum resistant and platinum sensitive that included the patients with tumor progression less than or more than six months, respectively. Clinical data for tumor progression in epithelial ovarian cancer patients treated at Chiang Mai University Hospital between January, 2006 and December, 2010 were reviewed. Thirty-nine patients were in the platinum refractory group while 27 were in the platinum resistant group and 75 in the platinum sensitive group. The mean age, the parity, the administration of neoadjuvant chemotherapy and the serous type did not significantly different across groups while the mean total number of chemotherapy regimens, the early stage patients, the patients with complete surgery and the surviving patients were significant more frequent in the platinum sensitive group. Regarding subsequent treatment after tumor recurrence, 87.2% underwent chemotherapy. With the median follow up time at 29 months, the median overall survival rates were 20 months, 14 months and 42 months in platinum refractory, platinum resistant and platinum sensitive groups, respectively (p < 0.001). In addition, when the platinum sensitive patients developed the next episode of tumor progression, the median progression free interval time was only three to four months. In conclusion, the outcomes for platinum refractory the and platinum resistant groups was poorer than the platinum sensitive group. However, subsequent progression in the platinum sensitive group was also associated with a poor outcome. 2015-06-16T07:47:08Z 2015-06-16T07:47:08Z 2014-01-01 Article 15137368 2-s2.0-84922989473 10.7314/APJCP.2014.15.24.10837 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922989473&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38392 Asian Pacific Organization for Cancer Prevention
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
spellingShingle Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
Jansaka,N.
Suprasert,P.
Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center
description To assess survival outcomes in a retrospective study, recurrent epithelial ovarian cancer patients were divided into three groups according to the platinum free interval as follows: platinum refractory that included the patients with tumor progression during treatment; platinum resistant and platinum sensitive that included the patients with tumor progression less than or more than six months, respectively. Clinical data for tumor progression in epithelial ovarian cancer patients treated at Chiang Mai University Hospital between January, 2006 and December, 2010 were reviewed. Thirty-nine patients were in the platinum refractory group while 27 were in the platinum resistant group and 75 in the platinum sensitive group. The mean age, the parity, the administration of neoadjuvant chemotherapy and the serous type did not significantly different across groups while the mean total number of chemotherapy regimens, the early stage patients, the patients with complete surgery and the surviving patients were significant more frequent in the platinum sensitive group. Regarding subsequent treatment after tumor recurrence, 87.2% underwent chemotherapy. With the median follow up time at 29 months, the median overall survival rates were 20 months, 14 months and 42 months in platinum refractory, platinum resistant and platinum sensitive groups, respectively (p < 0.001). In addition, when the platinum sensitive patients developed the next episode of tumor progression, the median progression free interval time was only three to four months. In conclusion, the outcomes for platinum refractory the and platinum resistant groups was poorer than the platinum sensitive group. However, subsequent progression in the platinum sensitive group was also associated with a poor outcome.
format Article
author Jansaka,N.
Suprasert,P.
author_facet Jansaka,N.
Suprasert,P.
author_sort Jansaka,N.
title Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center
title_short Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center
title_full Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center
title_fullStr Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center
title_full_unstemmed Survival outcomes of recurrent epithelial ovarian cancer: Experience from a Thailand Northern tertiary care center
title_sort survival outcomes of recurrent epithelial ovarian cancer: experience from a thailand northern tertiary care center
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84922989473&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38392
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