Testosterone deficiency, insulin-resistant obesity and cognitive function

© 2015 Springer Science+Business Media New York Testosterone is an androgenic steroid hormone, which plays an important role in the regulation of male reproduction and behaviors, as well as in the maintenance of insulin sensitivity. Several studies showed that testosterone exerted beneficial effects...

Full description

Saved in:
Bibliographic Details
Main Authors: Pintana,H., Chattipakorn,N., Chattipakorn,S.C.
Format: Article
Published: Springer New York 2015
Subjects:
Online Access:http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923239706&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38400
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-38400
record_format dspace
spelling th-cmuir.6653943832-384002015-06-16T07:47:09Z Testosterone deficiency, insulin-resistant obesity and cognitive function Pintana,H. Chattipakorn,N. Chattipakorn,S.C. Biochemistry Neurology (clinical) Cellular and Molecular Neuroscience © 2015 Springer Science+Business Media New York Testosterone is an androgenic steroid hormone, which plays an important role in the regulation of male reproduction and behaviors, as well as in the maintenance of insulin sensitivity. Several studies showed that testosterone exerted beneficial effects in brain function, including preventing neuronal cell death, balancing brain oxidative stress and antioxidant activity, improving synaptic plasticity and involving cognitive formation. Although previous studies showed that testosterone deficiency is positively correlated with cognitive impairment and insulin-resistant obesity, several studies demonstrated contradictory findings. Thus, this review comprehensively summarizes the current evidence from in vitro, in vivo and clinical studies of the relationship between testosterone deficiency and insulin-resistant obesity as well as the correlation between either insulin-resistant obesity or testosterone deficiency and cognitive impairment. Controversial reports and the mechanistic insights regarding the roles of testosterone in insulin-resistant obesity and cognitive function are also presented and discussed. 2015-06-16T07:47:09Z 2015-06-16T07:47:09Z 2015-02-24 Article in Press 08857490 2-s2.0-84923239706 10.1007/s11011-015-9655-3 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923239706&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38400 Springer New York
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Biochemistry
Neurology (clinical)
Cellular and Molecular Neuroscience
spellingShingle Biochemistry
Neurology (clinical)
Cellular and Molecular Neuroscience
Pintana,H.
Chattipakorn,N.
Chattipakorn,S.C.
Testosterone deficiency, insulin-resistant obesity and cognitive function
description © 2015 Springer Science+Business Media New York Testosterone is an androgenic steroid hormone, which plays an important role in the regulation of male reproduction and behaviors, as well as in the maintenance of insulin sensitivity. Several studies showed that testosterone exerted beneficial effects in brain function, including preventing neuronal cell death, balancing brain oxidative stress and antioxidant activity, improving synaptic plasticity and involving cognitive formation. Although previous studies showed that testosterone deficiency is positively correlated with cognitive impairment and insulin-resistant obesity, several studies demonstrated contradictory findings. Thus, this review comprehensively summarizes the current evidence from in vitro, in vivo and clinical studies of the relationship between testosterone deficiency and insulin-resistant obesity as well as the correlation between either insulin-resistant obesity or testosterone deficiency and cognitive impairment. Controversial reports and the mechanistic insights regarding the roles of testosterone in insulin-resistant obesity and cognitive function are also presented and discussed.
format Article
author Pintana,H.
Chattipakorn,N.
Chattipakorn,S.C.
author_facet Pintana,H.
Chattipakorn,N.
Chattipakorn,S.C.
author_sort Pintana,H.
title Testosterone deficiency, insulin-resistant obesity and cognitive function
title_short Testosterone deficiency, insulin-resistant obesity and cognitive function
title_full Testosterone deficiency, insulin-resistant obesity and cognitive function
title_fullStr Testosterone deficiency, insulin-resistant obesity and cognitive function
title_full_unstemmed Testosterone deficiency, insulin-resistant obesity and cognitive function
title_sort testosterone deficiency, insulin-resistant obesity and cognitive function
publisher Springer New York
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923239706&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38400
_version_ 1681421466754613248