Prevalence and correlates of HPV among women attending family-planning clinics in Thailand

• Main Authors: Marks,M.A., Gupta,S.B., Liaw,K., Tadesse,A.S., Kim,E., Phongnarisorn,C., Wootipoom,V., Yuenyao,P., Vipupinyo,C., Rugpao,S., Sriplienchan,S., Gravitt,P.E., Celentano,D.D.
• Format: Article
• Published: BioMed Central 2015
• Subjects: Infectious Diseases
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84926362012&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38449
• Institution: Chiang Mai University

© Marks et al. Background: Cervical cancer is the most common cancer among women of reproductive age in Thailand. However, information on the prevalence and correlates of anogenital HPV infection in Thailand is sparse. Methods: HPV genotype information, reproductive factors, sexual behavior, other STI and clinical information, and cervical cytology and histology were assessed at enrollment among one thousand two hundred and fifty-six (n = 1,256) HIV negative women aged 20-37 from Thailand enrolled in a prospective study of the natural history of HPV. The type-specific prevalence of HPV was estimated using cervical swab specimens from healthy women and women with a diagnosis of CIN 2/3 at baseline. Prevalence ratios (95% CI) were estimated using Poisson regression to quantify the association of demographic, behavioral, and clinical correlates with prevalent HPV infection. Results: Overall, 307 (24.6%) and 175 (14.0%) of women were positive for any HPV type and any HR-HPV type, respectively; the most common types were 72, 52, 62, and 16. Among women diagnosed with CIN 2/3 at enrollment (n = 11), the most prevalent HPV types were 52 and 16. In multivariate analysis, HPV prevalence at enrollment was higher among women with: long-term combined oral contraceptive use, a higher number of lifetime sexual partners, a prior Chlamydia infection, and a current diagnosis of Bacterial Vaginosis. Conclusion: The study findings provide important information that can be used in the evaluation of primary and secondary interventions designed to reduce the burden of cervical cancer in Thailand.