First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex
© 2014 Pothirat et al. Since 1996, there have been several case reports of autochthonous visceral leishmaniasis in Thailand. Here we report a case in a 52-year-old Thai male from northern Thailand, who presented with subacute fever, huge splenomegaly and pancytopenia. Bone marrow aspiration revealed...
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th-cmuir.6653943832-384672015-06-16T07:47:17Z First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex Pothirat,T. Tantiworawit,A. Chaiwarith,R. Jariyapan,N. Wannasan,A. Siriyasatien,P. Supparatpinyo,K. Bates,M.D. Kwakye-Nuako,G. Bates,P.A. Pharmacology, Toxicology and Pharmaceutics (all) Infectious Diseases Public Health, Environmental and Occupational Health © 2014 Pothirat et al. Since 1996, there have been several case reports of autochthonous visceral leishmaniasis in Thailand. Here we report a case in a 52-year-old Thai male from northern Thailand, who presented with subacute fever, huge splenomegaly and pancytopenia. Bone marrow aspiration revealed numerous amastigotes within macrophages. Isolation of Leishmania LSCM1 into culture and DNA sequence analysis (ribosomal RNA ITS-1 and large subunit of RNA polymerase II) revealed the parasites to be members of the Leishmania enriettii complex, and apparently identical to L. martiniquensis previously reported from the Caribbean island of Martinique. This is the first report of visceral leishmaniasis caused by L. martiniquensis from the region. Moreover, the majority of parasites previously identified as “L. siamensis” also appear to be L. martiniquensis. 2015-06-16T07:47:17Z 2015-06-16T07:47:17Z 2014-12-04 Article 19352727 2-s2.0-84928227092 10.1371/journal.pntd.0003339 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928227092&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38467 Public Library of Science |
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Pharmacology, Toxicology and Pharmaceutics (all) Infectious Diseases Public Health, Environmental and Occupational Health |
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Pharmacology, Toxicology and Pharmaceutics (all) Infectious Diseases Public Health, Environmental and Occupational Health Pothirat,T. Tantiworawit,A. Chaiwarith,R. Jariyapan,N. Wannasan,A. Siriyasatien,P. Supparatpinyo,K. Bates,M.D. Kwakye-Nuako,G. Bates,P.A. First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex |
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© 2014 Pothirat et al. Since 1996, there have been several case reports of autochthonous visceral leishmaniasis in Thailand. Here we report a case in a 52-year-old Thai male from northern Thailand, who presented with subacute fever, huge splenomegaly and pancytopenia. Bone marrow aspiration revealed numerous amastigotes within macrophages. Isolation of Leishmania LSCM1 into culture and DNA sequence analysis (ribosomal RNA ITS-1 and large subunit of RNA polymerase II) revealed the parasites to be members of the Leishmania enriettii complex, and apparently identical to L. martiniquensis previously reported from the Caribbean island of Martinique. This is the first report of visceral leishmaniasis caused by L. martiniquensis from the region. Moreover, the majority of parasites previously identified as “L. siamensis” also appear to be L. martiniquensis. |
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Article |
author |
Pothirat,T. Tantiworawit,A. Chaiwarith,R. Jariyapan,N. Wannasan,A. Siriyasatien,P. Supparatpinyo,K. Bates,M.D. Kwakye-Nuako,G. Bates,P.A. |
author_facet |
Pothirat,T. Tantiworawit,A. Chaiwarith,R. Jariyapan,N. Wannasan,A. Siriyasatien,P. Supparatpinyo,K. Bates,M.D. Kwakye-Nuako,G. Bates,P.A. |
author_sort |
Pothirat,T. |
title |
First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex |
title_short |
First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex |
title_full |
First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex |
title_fullStr |
First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex |
title_full_unstemmed |
First Isolation of Leishmania from Northern Thailand: Case Report, Identification as Leishmania martiniquensis and Phylogenetic Position within the Leishmania enriettii Complex |
title_sort |
first isolation of leishmania from northern thailand: case report, identification as leishmania martiniquensis and phylogenetic position within the leishmania enriettii complex |
publisher |
Public Library of Science |
publishDate |
2015 |
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http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928227092&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38467 |
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1681421478899220480 |