Enterocarpam-III induces human liver and breast cancer cell apoptosis via mitochondrial and caspase-9 activation

• Main Authors: Banjerdpongchai,R., Wudtiwai,B., Pompimon,W.
• Format: Article
• Published: Asian Pacific Organization for Cancer Prevention 2015
• Subjects: Cancer Research; Oncology; Epidemiology; Public Health, Environmental and Occupational Health
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84928534379&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38468
• Institution: Chiang Mai University

An aristolactam-type alkaloid, isolated from Orophea enterocarpa, is enterocarpam-III (10-amino-2,3,4,6-tetramethoxyphenanthrene-1-carboxylic acid lactam). It is cytotoxic to various human and murine cancer cell lines; however, the molecular mechanisms remain unclear. The aims of this study were to...