High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand

© 2015 Supindham et al. Background: HPV infection is common and may cause cancer among men who have sex with men (MSM). Anal HPV infection (HPV+) was found in 85% of HIV-positive (HIV+) and 59% of HIV-negative (HIV-) MSM in Bangkok, central Thailand. As little is known about HPV in this group in nor...

Full description

Saved in:
Bibliographic Details
Main Authors: Supindham T., Chariyalertsak S., Utaipat U., Miura T., Ruanpeng D., Chotirosniramit N., Kosashunhanan N., Sugandhavesa P., Saokhieo P., Songsupa R., Siriaunkgul S., Wongthanee A.
Format: Article
Published: Public Library of Science 2015
Subjects:
Online Access:http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929207817&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38483
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
id th-cmuir.6653943832-38483
record_format dspace
spelling th-cmuir.6653943832-384832015-06-16T07:47:19Z High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand Supindham T. Chariyalertsak S. Utaipat U. Miura T. Ruanpeng D. Chotirosniramit N. Kosashunhanan N. Sugandhavesa P. Saokhieo P. Songsupa R. Siriaunkgul S. Wongthanee A. Medicine (all) Biochemistry, Genetics and Molecular Biology (all) Agricultural and Biological Sciences (all) © 2015 Supindham et al. Background: HPV infection is common and may cause cancer among men who have sex with men (MSM). Anal HPV infection (HPV+) was found in 85% of HIV-positive (HIV+) and 59% of HIV-negative (HIV-) MSM in Bangkok, central Thailand. As little is known about HPV in this group in northern Thailand, we studied MSM subgroups comprised of gay men (GM), bisexual men (BM), and transgender women (TGW). Methods: From July 2012 through January 2013, 85 (42.5% of 200) GM, 30 (15%) BM, and 85 (42.5%) TGW who practiced receptive anal intercourse were recruited after informed consent, followed by self-assisted computer interview, HIV testing, and anal swabs for HPV genotyping. Results: Of 197 adequate specimens, the overall prevalence of any HPV was 157 (80%). Prevalence was 89% (76/85) in GM, 48% (14/29) in BM, and 81% (67/83) in TGW. The most common high-risk types were HPV16 (27% of 197), HPV58 (23%), and HPV51 (18%). Prevalence of high-risk types was 74% in 85 GM, 35% in 29 BM, and 71% in 83 TGW. Prevalence of any HPV type, or high-risk type, was 100% and 94%, respectively, among 48 HIV+ MSM, 70% and 54% among 120 HIV- MSM. Of the 197 specimens, 36% (70) had HPV types 16 and/or 18 in the bivalent vaccine, compared to 48% (95) with ≥1 of types 16/18/06/11 in the quadrivalent, 56% (111) for 16/18/31/33/45/52/58 in the 7-valent, and 64% (126) for 16/18/31/33/45/52/58/06/11 in the 9-valent. HIV+, GM, and TGW were independently associated with HPV infection. Conclusions: We found higher rates of both any HPV and high-risk types than previous studies. Among the heretofore unstudied TGW, their equivalent HPV rates were comparable to GM. Current and investigational HPV vaccines could substantially protect GM, BM, and TGW from the serious consequences of HPV infection especially among HIV + MSM. 2015-06-16T07:47:19Z 2015-06-16T07:47:19Z 2015-05-01 Article 19326203 2-s2.0-84929207817 10.1371/journal.pone.0124499 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929207817&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38483 Public Library of Science
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Medicine (all)
Biochemistry, Genetics and Molecular Biology (all)
Agricultural and Biological Sciences (all)
spellingShingle Medicine (all)
Biochemistry, Genetics and Molecular Biology (all)
Agricultural and Biological Sciences (all)
Supindham T.
Chariyalertsak S.
Utaipat U.
Miura T.
Ruanpeng D.
Chotirosniramit N.
Kosashunhanan N.
Sugandhavesa P.
Saokhieo P.
Songsupa R.
Siriaunkgul S.
Wongthanee A.
High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand
description © 2015 Supindham et al. Background: HPV infection is common and may cause cancer among men who have sex with men (MSM). Anal HPV infection (HPV+) was found in 85% of HIV-positive (HIV+) and 59% of HIV-negative (HIV-) MSM in Bangkok, central Thailand. As little is known about HPV in this group in northern Thailand, we studied MSM subgroups comprised of gay men (GM), bisexual men (BM), and transgender women (TGW). Methods: From July 2012 through January 2013, 85 (42.5% of 200) GM, 30 (15%) BM, and 85 (42.5%) TGW who practiced receptive anal intercourse were recruited after informed consent, followed by self-assisted computer interview, HIV testing, and anal swabs for HPV genotyping. Results: Of 197 adequate specimens, the overall prevalence of any HPV was 157 (80%). Prevalence was 89% (76/85) in GM, 48% (14/29) in BM, and 81% (67/83) in TGW. The most common high-risk types were HPV16 (27% of 197), HPV58 (23%), and HPV51 (18%). Prevalence of high-risk types was 74% in 85 GM, 35% in 29 BM, and 71% in 83 TGW. Prevalence of any HPV type, or high-risk type, was 100% and 94%, respectively, among 48 HIV+ MSM, 70% and 54% among 120 HIV- MSM. Of the 197 specimens, 36% (70) had HPV types 16 and/or 18 in the bivalent vaccine, compared to 48% (95) with ≥1 of types 16/18/06/11 in the quadrivalent, 56% (111) for 16/18/31/33/45/52/58 in the 7-valent, and 64% (126) for 16/18/31/33/45/52/58/06/11 in the 9-valent. HIV+, GM, and TGW were independently associated with HPV infection. Conclusions: We found higher rates of both any HPV and high-risk types than previous studies. Among the heretofore unstudied TGW, their equivalent HPV rates were comparable to GM. Current and investigational HPV vaccines could substantially protect GM, BM, and TGW from the serious consequences of HPV infection especially among HIV + MSM.
format Article
author Supindham T.
Chariyalertsak S.
Utaipat U.
Miura T.
Ruanpeng D.
Chotirosniramit N.
Kosashunhanan N.
Sugandhavesa P.
Saokhieo P.
Songsupa R.
Siriaunkgul S.
Wongthanee A.
author_facet Supindham T.
Chariyalertsak S.
Utaipat U.
Miura T.
Ruanpeng D.
Chotirosniramit N.
Kosashunhanan N.
Sugandhavesa P.
Saokhieo P.
Songsupa R.
Siriaunkgul S.
Wongthanee A.
author_sort Supindham T.
title High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand
title_short High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand
title_full High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand
title_fullStr High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand
title_full_unstemmed High prevalence and genotype diversity of anal HPV infection among MSM in Northern Thailand
title_sort high prevalence and genotype diversity of anal hpv infection among msm in northern thailand
publisher Public Library of Science
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929207817&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38483
_version_ 1681421481788047360