Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women

Background: The aim of this study was to analyze the patterns of relapse and survival outcomes in Northern Thai women with recurrent endometrial cancer (EC). Materials and Methods: Medical records were abstracted from EC patients who underwent primary surgery from 1999 to 2012. Data on clinicopathol...

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Main Authors: Kaewpangchan P., Cheewakriangkrai C.
Format: Article
Published: Asian Pacific Organization for Cancer Prevention 2015
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spelling th-cmuir.6653943832-385112015-06-16T07:47:23Z Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women Kaewpangchan P. Cheewakriangkrai C. Cancer Research Oncology Epidemiology Public Health, Environmental and Occupational Health Background: The aim of this study was to analyze the patterns of relapse and survival outcomes in Northern Thai women with recurrent endometrial cancer (EC). Materials and Methods: Medical records were abstracted from EC patients who underwent primary surgery from 1999 to 2012. Data on clinicopathologic variables, sites of first recurrence, time to relapse of disease, and overall survival (OS) was analyzed. Associations between the clinicopathological variables and the rates of disease recurrence were determined. Results: Among 1,204 reviewed records, 42 eligible patients were identified with recurrent disease. The median age was 55 years and the median follow-up time was 26.0 months. The median times to recurrence (TTR) after completion of the initial treatment in the group of local relapse (LR) and distant/combined sites of recurrence (DCSR) was 6.6 (95% CI=4.6 to 8.6 months) and 16.9 months (95% CI=5.6 to 28.2 months), respectively (p=0.36). The 2-year survival and 3-year survival probability in the group of LR was 54.2% (95% CI=27.2 to 81.3%) and 34.7% (95% CI=9.2 to 60.2%), compared to 50.4% (95% CI=41.1 to 59.7%) and 42.1% (95%CI= 24.1 to 60.1%) for those with DCSR. Distant recurrence was the most frequent pattern of relapse. Overall survival was not significantly different in patients with local relapse when compared to those with DCSR (p=0.69). Conclusions: Patients with recurrence of EC after primary treatment had a worse prognosis and clinical aggressiveness. LR and DCSR occurred most during the first three years. The common sites of relapses were vaginal cuff, pelvis, and lungs. No significant clinicopathological predictor for survival outcomes was identified. 2015-06-16T07:47:23Z 2015-06-16T07:47:23Z 2015-01-01 Article 15137368 2-s2.0-84930158486 10.7314/APJCP.2015.16.9.3861 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930158486&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38511 Asian Pacific Organization for Cancer Prevention
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
topic Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
spellingShingle Cancer Research
Oncology
Epidemiology
Public Health, Environmental and Occupational Health
Kaewpangchan P.
Cheewakriangkrai C.
Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women
description Background: The aim of this study was to analyze the patterns of relapse and survival outcomes in Northern Thai women with recurrent endometrial cancer (EC). Materials and Methods: Medical records were abstracted from EC patients who underwent primary surgery from 1999 to 2012. Data on clinicopathologic variables, sites of first recurrence, time to relapse of disease, and overall survival (OS) was analyzed. Associations between the clinicopathological variables and the rates of disease recurrence were determined. Results: Among 1,204 reviewed records, 42 eligible patients were identified with recurrent disease. The median age was 55 years and the median follow-up time was 26.0 months. The median times to recurrence (TTR) after completion of the initial treatment in the group of local relapse (LR) and distant/combined sites of recurrence (DCSR) was 6.6 (95% CI=4.6 to 8.6 months) and 16.9 months (95% CI=5.6 to 28.2 months), respectively (p=0.36). The 2-year survival and 3-year survival probability in the group of LR was 54.2% (95% CI=27.2 to 81.3%) and 34.7% (95% CI=9.2 to 60.2%), compared to 50.4% (95% CI=41.1 to 59.7%) and 42.1% (95%CI= 24.1 to 60.1%) for those with DCSR. Distant recurrence was the most frequent pattern of relapse. Overall survival was not significantly different in patients with local relapse when compared to those with DCSR (p=0.69). Conclusions: Patients with recurrence of EC after primary treatment had a worse prognosis and clinical aggressiveness. LR and DCSR occurred most during the first three years. The common sites of relapses were vaginal cuff, pelvis, and lungs. No significant clinicopathological predictor for survival outcomes was identified.
format Article
author Kaewpangchan P.
Cheewakriangkrai C.
author_facet Kaewpangchan P.
Cheewakriangkrai C.
author_sort Kaewpangchan P.
title Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women
title_short Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women
title_full Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women
title_fullStr Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women
title_full_unstemmed Relapse patterns and outcomes following recurrence of endometrial cancer in Northern Thai women
title_sort relapse patterns and outcomes following recurrence of endometrial cancer in northern thai women
publisher Asian Pacific Organization for Cancer Prevention
publishDate 2015
url http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930158486&origin=inward
http://cmuir.cmu.ac.th/handle/6653943832/38511
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