Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes

• Main Authors: Toegel,S., Wu,S., Otero,M.A., Goldring,M.B., Leelapornpisid,P., Chiari,C., Kolb,A., Unger,F.M., Windhager,R., Viernstein,H.
• Format: Article
• Published: Springer Verlag 2015
• Subjects: Endocrinology, Diabetes and Metabolism; Genetics
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84860772136&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38525
• Institution: Chiang Mai University

Exacerbated production of matrix metalloproteinases (MMPs) is a key event in the progression of osteoarthritis (OA) and represents a promising target for the management of OA with nutraceuticals. In this study, we sought to determine the MMP-inhibitory activity of an ethanolic Caesalpinia sappan ext...