OXPIRT: Ontology-based eXpert system for Production of a generic Immediate Release Tablet

• Main Authors: Chalortham,N., Ruangrajitpakorn,T., Supnithi,T., Leesawat,P.
• Format: Chapter
• Published: 2015
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84904140671&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38541
• Institution: Chiang Mai University

We introduce an ontology based expert system for suggesting production of an immediately released tablet in generic version called OXPIRT. It was designed to assist pharmacists by providing a list of ingredients in formulation, a manufacturing process, a step-by-step instruction of laboratorial scale production for testing, and a validation in terms of pharmaceutical equivalence to the original drug. For practical usage and efficacy, the domain knowledge of an original drug and a generic drug production from a regulated guidebook and expired patents is represented in ontology format while the operational knowledge for calculating a formulation and suggesting a manufacturing process is given in the production rules. Experiments were conducted on four drugs to approve its capability, and we found that the system worked very well on recommending a generic table production in an actual situation. © 2013 Woodhead Publishing Limited. All rights reserved.