Carbopol®-guar gum gel as a vehicle for topical gel formulation of pectin beads loaded with rutin

• Main Authors: Jantrawut,P., Ruksiriwanich,W.
• Format: Article
• Published: Asian Journal of Pharmaceutical and Clinical Research 2015
• Subjects: Pharmaceutical Science; Pharmacology; Pharmacology (medical)
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84907096774&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38548
• Institution: Chiang Mai University

© 2014 Asian Journal of Pharmaceutical and Clinical Research. All rights reserved. Objective: The aim of this study was to develop suitable pharmaceutical gel formulations of pectin beads using semisynthetic celluloses or synthetic carbomers as a gelling agent. Materials and Methods: Low methoxyl pectin (LMP) beads loaded with rutin composing 3% non-amidated LMP, 15% sorbitol and 1% sodium bicarbonate with 2% w/v of rutin were prepared, characterized, incorporated in various pharmaceutical gel bases and evaluated for rabbit skin irritation by close patch test. Results: Rutin wetted bead formulation which showed spherical shape (around 700 μm), high rutin encapsulation efficiencies (82.02±0.91%), low conductivity (900 μS at 30 minutes) and faster rutin release (more than 80% in 30 minutes) was selected to incorporate in gel. The wetted rutin beads exhibited good stability (beads suspended in gel without breaking or gel color changing) in the gel composed of 0.4% w/v Carbopol® Ultrez 21 with 0.04% w/v guar gum at pH 5.0. Conclusion: Rutin wetted beads in developed pharmaceutical gel formulation showed higher percentages of rutin remaining when stored at room temperature (27±2°C) than non-loaded rutin of about 1.53 times and gave no irritation in rabbit skin irritation test, however, the safety on human skin applications should be confirmed.