Anti-gastric ulcer and acute oral toxicity of aqueous extract of turbinaria conoides from the gulf of Thailand

• Main Authors: Boonchum W., Vacharapiyasophon P., Kanjanapothi D., Pekkoh J., Amornlerdpison D., Pumas C., Peerapornpisal Y.
• Format: Article
• Published: Chiang Mai University 2015
• Subjects: Physics and Astronomy (all); Chemistry (all); Materials Science (all); Mathematics (all); Biochemistry, Genetics and Molecular Biology (all)
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84870184555&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38645
• Institution: Chiang Mai University

Turbinaria conoides is a brown marine alga which was collected from the Gulf Thailand. In previous studies, aqueous extract (AE) of T. conoides have shown a potential in performing beneficial activities, including antioxidative, antimicrobial and anti-inflammatory activities. In this report, the potential of T. conoides as a protectant against gastric ulcers resulting from restraint water immersion stress, mixture of HCl/ethanol and indomethacin induced gastric ulcer in rats were studied. AE of T. conoides could reduce gastric ulceration in all assays in the range of 50.98 - 99.85%. The highest activity was found in the HCl/ethanol model. Moreover, AE of T. conoides has non-oral toxicity in high dose. These results suggest that the AE of T. conoides could help protect the stomach from stress, indomethacin as well as HCl/ethanol induced gastric ulcers. Its safety as a neutraceutical or pharmaceutical product has also been determined.