Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma

We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivativ...

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Main Authors:	Pilapong,C., Sitthichai,S., Thongtem,S., Thongtem,T.
Format:	Article
Published:	Elsevier 2015
Subjects:	Pharmaceutical Science
Online Access:	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905453309&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38748
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Institution:	Chiang Mai University

id	th-cmuir.6653943832-38748
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spelling	th-cmuir.6653943832-387482015-06-16T07:54:08Z Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma Pilapong,C. Sitthichai,S. Thongtem,S. Thongtem,T. Pharmaceutical Science We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivative polymer, specific capability of cancer-specific molecule (DNA-based EpCAM aptamer) and the imaging capability of magnetic iron oxide nanoparticles. Our proof-of-concept design demonstrates efficient in vitro MR imaging of the cancer cells, and enhanced delivery of an anticancer drug into the cancer cells with comparable treatment efficacy. © 2014 Elsevier B.V. 2015-06-16T07:54:08Z 2015-06-16T07:54:08Z 2014-10-01 Article 03785173 2-s2.0-84905453309 10.1016/j.ijpharm.2014.07.036 http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905453309&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38748 Elsevier
institution	Chiang Mai University
building	Chiang Mai University Library
country	Thailand
collection	CMU Intellectual Repository
topic	Pharmaceutical Science
spellingShingle	Pharmaceutical Science Pilapong,C. Sitthichai,S. Thongtem,S. Thongtem,T. Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
description	We report herein the development of a smart magnetic nanoparticle-aptamer probe, or theranostic nanoprobe, which can be used for targeted imaging and as a drug carrier for hepatocellular carcinoma treatment. The theranostic nanoprobe combines the delivery potential of a non-toxic cellulose derivative polymer, specific capability of cancer-specific molecule (DNA-based EpCAM aptamer) and the imaging capability of magnetic iron oxide nanoparticles. Our proof-of-concept design demonstrates efficient in vitro MR imaging of the cancer cells, and enhanced delivery of an anticancer drug into the cancer cells with comparable treatment efficacy. © 2014 Elsevier B.V.
format	Article
author	Pilapong,C. Sitthichai,S. Thongtem,S. Thongtem,T.
author_facet	Pilapong,C. Sitthichai,S. Thongtem,S. Thongtem,T.
author_sort	Pilapong,C.
title	Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
title_short	Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
title_full	Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
title_fullStr	Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
title_full_unstemmed	Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
title_sort	smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma
publisher	Elsevier
publishDate	2015
url	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905453309&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/38748
_version_	1681421529817022464

Smart magnetic nanoparticle-aptamer probe for targeted imaging and treatment of hepatocellular carcinoma

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