Bioactive prenylated xanthones from the young fruits and flowers of Garcinia cowa

• Main Authors: Sriyatep,T., Siridechakorn,I., Maneerat,W., Pansanit,A., Ritthiwigrom,T., Andersen,R.J., Laphookhieo,S.
• Format: Article
• Published: American Chemical Society 2015
• Subjects: Analytical Chemistry; Drug Discovery; Pharmaceutical Science; Pharmacology; Molecular Medicine; Organic Chemistry; Complementary and Alternative Medicine
• Online Access: http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84923924283&origin=inward; http://cmuir.cmu.ac.th/handle/6653943832/38898
• Institution: Chiang Mai University

© 2015 The American Chemical Society and American Society of Pharmacognosy. Five new xanthones, garciniacowones A-E (1-5), together with 14 known xanthones, 6-19, were isolated from the young fruits and fresh flowers of Garcinia cowa. The structures of 1-5 were elucidated by analysis of their 1D and 2D NMR spectra and mass spectrometric data. The compounds 1-19 were tested in vitro for their antimicrobial activity and for their ability to inhibit α-glucosidase. Compounds 16 and 17 showed the most potent α-glucosidase inhibitory activity, with IC50 values of 7.8 ± 0.5 and 8.7 ± 0.3 μM, respectively. Compounds 8, 9, and 19 showed antibacterial activity against Bacillus subtilis TISTR 088 with identical MIC values of 2 μg/mL, while 8, 10, and 19 exhibited antibacterial activity against Bacillus cereus TISTR 688 with identical MIC values of 4 μg/mL.