Endoscopic evaluation of gastric mucosa to determine safety of three chondroprotective drugs in healthy dogs
This randomized, double-blind, placebo-controlled study investigated the effects of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein on the gastric mucosa of dogs, and on clinical signs of vomiting and diarrhea. Twenty-one healthy adult dogs were included in the study, and were ra...
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| Main Authors: | , , , |
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| Format: | Article |
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Chulalongkorn University
2015
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| Online Access: | http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84897945619&origin=inward http://cmuir.cmu.ac.th/handle/6653943832/39175 |
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| Institution: | Chiang Mai University |
| Summary: | This randomized, double-blind, placebo-controlled study investigated the effects of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein on the gastric mucosa of dogs, and on clinical signs of vomiting and diarrhea. Twenty-one healthy adult dogs were included in the study, and were randomly assigned to seven treatment groups, 3 dogs per group. The effect of those medicines on the gastric mucosa was evaluated by endoscopy on day 3 and day 14, and compared with pre-treatment. Clinical signs, including vomiting and diarrhea, were recorded every day during the study period. The results showed a non-significant effect of glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein on gastric mucosal lesions in healthy dogs. One dog vomited after receiving glucosamine/chondroitin sulfate, but only for the first 2 days. All dogs receiving diacerein showed symptoms of diarrhea during the 14-day trial. In conclusion, glucosamine/chondroitin sulfate, chondroitin sulfate, and diacerein at doses of 1,500 and 3,000 mg/day are gastric-safe for use in dogs. |
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