Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D

A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a s...

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Main Authors: Manopunya M., Suprasert P.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/22502707
http://cmuir.cmu.ac.th/handle/6653943832/4004
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-40042014-08-30T02:35:33Z Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D Manopunya M. Suprasert P. A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a salvage setting was unclear. To evaluate the efficacy and safety of the 5 FU plus Act D regimen utilized in this condition, all GTN patients resistant to at least three previous chemotherapy regimens who received the 5 FU plus Act D regimen between August 2009 and January 2011 at Chiang Mai University Hospital were reviewed. There were five cases who met the criteria. Four of those patients were in FIGO stage III to IV with a WHO scoring of more than 12. The median number of cycles for each patient was two and only one case achieved remission while four of the cases were unresponsive. The toxicity was evaluated in 12 cycles. Common complications were uncomplicated myelosuppression and mucositis. In conclusion, this regimen revealed modest efficacy in a salvage setting with manageable toxicity. 2014-08-30T02:35:33Z 2014-08-30T02:35:33Z 2012 Journal Article 1513-7368 22502707 http://www.ncbi.nlm.nih.gov/pubmed/22502707 http://cmuir.cmu.ac.th/handle/6653943832/4004 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description A combination of 5-fluorouracil plus actinomycin D (5FU plus Act D) is the regimen that has been commonly administered to Chinese and Japanese gestational trophoblastic neoplasia patients as the first or second line of treatment with an excellent outcome. However, the efficacy of this regimen in a salvage setting was unclear. To evaluate the efficacy and safety of the 5 FU plus Act D regimen utilized in this condition, all GTN patients resistant to at least three previous chemotherapy regimens who received the 5 FU plus Act D regimen between August 2009 and January 2011 at Chiang Mai University Hospital were reviewed. There were five cases who met the criteria. Four of those patients were in FIGO stage III to IV with a WHO scoring of more than 12. The median number of cycles for each patient was two and only one case achieved remission while four of the cases were unresponsive. The toxicity was evaluated in 12 cycles. Common complications were uncomplicated myelosuppression and mucositis. In conclusion, this regimen revealed modest efficacy in a salvage setting with manageable toxicity.
format Article
author Manopunya M.
Suprasert P.
spellingShingle Manopunya M.
Suprasert P.
Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D
author_facet Manopunya M.
Suprasert P.
author_sort Manopunya M.
title Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D
title_short Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D
title_full Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D
title_fullStr Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D
title_full_unstemmed Resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin D
title_sort resistant gestational trophoblastic neoplasia patients treated with 5-fluorouracil plus actinomycin d
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/22502707
http://cmuir.cmu.ac.th/handle/6653943832/4004
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