Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf>
© 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph 3 P-I 2 -mediated forma...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Journal |
| Published: |
2017
|
| Online Access: | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027057783&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40189 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Chiang Mai University |
| id |
th-cmuir.6653943832-40189 |
|---|---|
| record_format |
dspace |
| spelling |
th-cmuir.6653943832-401892017-09-28T04:08:11Z Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> Phakhodee W. Wangngae S. Pattarawarapan M. © 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph 3 P-I 2 -mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions. 2017-09-28T04:08:11Z 2017-09-28T04:08:11Z 15 Journal 00223263 2-s2.0-85027057783 10.1021/acs.joc.7b01322 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027057783&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40189 |
| institution |
Chiang Mai University |
| building |
Chiang Mai University Library |
| country |
Thailand |
| collection |
CMU Intellectual Repository |
| description |
© 2017 American Chemical Society. Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves Ph 3 P-I 2 -mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions. |
| format |
Journal |
| author |
Phakhodee W. Wangngae S. Pattarawarapan M. |
| spellingShingle |
Phakhodee W. Wangngae S. Pattarawarapan M. Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| author_facet |
Phakhodee W. Wangngae S. Pattarawarapan M. |
| author_sort |
Phakhodee W. |
| title |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_short |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_full |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_fullStr |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_full_unstemmed |
Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph<inf>3</inf>P-I<inf>2</inf> |
| title_sort |
approach to the synthesis of 2,3-disubstituted-3h-quinazolin-4-ones mediated by ph<inf>3</inf>p-i<inf>2</inf> |
| publishDate |
2017 |
| url |
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85027057783&origin=inward http://cmuir.cmu.ac.th/jspui/handle/6653943832/40189 |
| _version_ |
1681421763991306240 |